Different approaches to enhance healing of hard or soft tissues include the use cytokines and growth factors modify cellular behaviour. Numerous are found in autologous blood concentrates - platelet-rich plasma (PRP) fibrin (PRF). Enamel matrix derivative (EMD) may improve tissue via amelogenins. Bilayered collagen (CM) is used for augmentation. The aim present study was assess potential benefi...

Background: Platelet-rich plasma (PRP) is blood containing an above baseline level of platelets and growth factors. Recently, has come to the attention aesthetic surgeons, with burgeoning new applications ranging from hair restoration soft tissue augmentation. Injectable Poly-D,L-Lactic Acid (PDLLA) a biostimulator rather than traditional filler, which provides immediate volumetric improvement....

A series of indole-based aryl(aroyl)hydrazone analogs of antiplatelet indole-3-carboxaldehyde phenylhydrazone were synthesized by the Schiff base formation reaction and their antiplatelet activity was assessed using human platelet rich plasma. The platelet concentrate was obtained using a two-step centrifugation protocol and ADP, arachidonic acid and collagen were used as inducers of platelet a...

A series of indole-based aryl(aroyl)hydrazone analogs of antiplatelet indole-3-carboxaldehyde phenylhydrazone were synthesized by the Schiff base formation reaction and their antiplatelet activity was assessed using human platelet rich plasma. The platelet concentrate was obtained using a two-step centrifugation protocol and ADP, arachidonic acid and collagen were used as inducers of platelet a...

CONTEXT Platelet-rich plasma (PRP) may affect soft tissue healing via growth factors released after platelet degranulation. Because of this potential benefit, clinicians have begun to inject PRP for the treatment of tendon, ligament, muscle, and cartilage injuries and early osteoarthritis. EVIDENCE ACQUISITION A PubMed search was performed for studies relating to PRP, growth factors, and soft...

OBJECTIVES The purpose of this study was to compare the quantity and quality of platelets in platelet-rich plasma (PRP) samples prepared using either the single- or the double-centrifugation protocol. METHODS Ten adult white New Zealand rabbits were used. Ten ml of blood were drawn from each animal via cardiac puncture. Each blood sample was divided into two equal parts for PRP preparation: 5...

OBJECTIVE To quantify and draw inferences on the clinical effectiveness of platelet-rich therapy in the management of patients with a typical osteoporotic fracture of the hip. DESIGN Single centre, parallel group, participant-blinded, randomised controlled trial. SETTING UK Major Trauma Centre. PARTICIPANTS 200 of 315 eligible patients aged 65 years and over with any type of intracapsular...