Mutations in the human CACNA1F gene cause incomplete congenital stationary night blindness type 2 (CSNB2), a non-progressive, clinically heterogeneous retinal disorder. However, the molecular mechanisms underlying CSNB2 have not been fully explored. Here, we describe the positional cloning of a blind zebrafish mutant, wait until dark (wud), which encodes a zebrafish homolog of human CACNA1F. We...

the multiple reference frames (mrf) method is the most suitable method tosimulate impeller rotation in mixing systems. precise determination of stationaryand moving zones in mrf method leads to accurate results in mixing performance.in this research, the entire volume of mixing system was divided into two zones.the kinetic energy values were used to distinguish the zones with differentvelocitie...

Ribbon synapses of photoreceptor cells and bipolar neurons in the retina signal graded changes in light intensity via sustained release of neurotransmitter. One molecular specialization of retinal ribbon synapses is the expression of complexin protein subtypes Cplx3 and Cplx4, whereas conventional synapses express Cplx1 and Cplx2. Because complexins bind to the molecular machinery for synaptic ...

BACKGROUND The incidence of cerebrovascular accidents following aortic valve surgery remains a devastating complication. The aim of this study was to determine the number of potential embolic material arising during aortic valve replacement and to examine the efficacy of using ribbon gauze in the left ventricle during removal of the native valve and decalcification of the aortic annulus. METH...

Ribbon synapses of tonically releasing sensory neurons must provide a large pool of releasable vesicles for sustained release, while minimizing spontaneous release in the absence of stimulation. Complexins are presynaptic proteins that may accomplish this dual task at conventional synapses by interacting with the molecular machinery of synaptic vesicle fusion at the active zone to retard sponta...

Self-assembly, the process by which objects autonomously come together to form complex structures, is omnipresent in the physical world. A systematic study of self-assembly as a mathematical process has been initiated. The individual components are modelled as square tiles on the infinite two-dimensional plane. Each side of a tile is covered by a specific “glue”, and two adjacent tiles will sti...

Two-dimensional materials are popular in design of nanodevices. To improve bending stiffness few-layered graphene ribbon, the relative sliding between neighboring layers should be avoided by method such as bonding them together. In this study, new bonds ribbon formed ballistic C60 fullerenes from both surfaces ribbon. Collision effects evaluated through molecular dynamics simulations. The forma...

The RSK correspondence generalises the Robinson-Schensted correspondence by replacing permutation matrices by matrices with entries in N, and standard Young tableaux by semistandard ones. For r ∈ N>0, the Robinson-Schensted correspondence can be trivially extended, using the r-quotient map, to one between r-coloured permutations and pairs of standard r-ribbon tableaux built on a fixed r-core (t...

We introduce and investigate the ribbon groupoid associated with a Garside group. Under a technical hypothesis, we prove that this category is a Garside groupoid. We decompose this groupoid into a semi-direct product of two of its parabolic subgroupoids and provide a groupoid presentation. In order to established the latter result, we describe quasi-centralizers in Garside groups. All results h...