نتایج جستجو برای: rgd peptide

تعداد نتایج: 160707  

2010
Yoshiyuki Kumada Shuguang Zhang

We here report the development of two peptide scaffolds designed for periodontal ligament fibroblasts. The scaffolds consist of one of the pure self-assembling peptide scaffolds RADA16 through direct coupling to short biologically active motifs. The motifs are 2-unit RGD binding sequence PRG (PRGDSGYRGDS) and laminin cell adhesion motif PDS (PDSGR). RGD and laminin have been previously shown to...

Journal: :The Journal of biological chemistry 2000
M Gilbert W J Shaw J R Long K Nelson G P Drobny C M Giachelli P S Stayton

Extracellular matrix proteins play key roles in controlling the activities of osteoblasts and osteoclasts in bone remodeling. These bone-specific extracellular matrix proteins contain amino acid sequences that mediate cell adhesion, and many of the bone-specific matrix proteins also contain acidic domains that interact with the mineral surface and may orient the signaling domains. Here we repor...

Journal: :Faraday discussions 2008
Tanyarut Boontheekul Hyun-Joon Kong Susan X Hsiong Yen-Chen Huang L Mahadevan Herman Vandenburgh David J Mooney

Many functions of the extracellular matrix can be mimicked by small peptide fragments (e.g., arginine-glycine-aspartic acid (RGD) sequence) of the entire molecule, but the presentation of the peptides is critical to their effects on cells. It is likely that some effects of peptide presentation from biomaterials simply relate to the number of bonds formed between cell receptors and the adhesion ...

Journal: :Translational Vision Science & Technology 2017

Journal: :The Journal of Cell Biology 1991
S P Massia J A Hubbell

The synthetic peptide Gly-Arg-Gly-Asp-Tyr (GRGDY), which contains the RGD sequence of several adhesion molecules, was covalently grafted to the surface of otherwise poorly adhesive glass substrates and was used to determine the minimal number of ligand-receptor interactions required for complete spreading of human foreskin fibroblasts. Well-defined adhesion substrates were prepared with GRGDY b...

Journal: :The Journal of Cell Biology 1992
X Sun K Skorstengaard D F Mosher

Thrombospondin (TSP) contains the Arg-Gly-Asp (RGD) sequence that is thought to be important for cell adhesion mediated by several cell-surface integrin receptors. The RGD sequence is located in the type 3 repeat region of TSP that has multiple Ca2+ binding sites and is subject to a complex intramolecular thiol-disulfide isomerization. TSP that we isolated from thrombin-activated human platelet...

Journal: :Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2013
Junghan Lee Tae Sup Lee Jiyoung Ryu Sukmin Hong Moonsik Kang Kangbin Im Joo Hyun Kang Sang Moo Lim Sun Park Rita Song

UNLABELLED Multimodal nanoparticles have been extensively studied for target-specific imaging and therapy of various diseases, including cancer. In this study, radiolabeled arginine-glycine-aspartic acid (RGD)-functionalized Er(3+)/Yb(3+) co-doped NaGdF(4) upconversion nanophosphors (UCNPs) were synthesized and evaluated as a multimodal PET/MR/optical probe with tumor angiogenesis-specific targ...

Journal: :International journal of molecular medicine 2006
Ursula Magdolen Jörg Auernheimer Claudia Dahmen Johannes Schauwecker Hans Gollwitzer Jutta Tübel Reiner Gradinger Horst Kessler Manfred Schmitt Peter Diehl

In tissue engineering, the application of biofunctional compounds on biomaterials such as integrin binding RGD-peptides has gained growing interest. Anchorage-dependent cells like osteoblasts bind to these peptides thus ameliorating the integration of a synthetic implant. In case sterilized bone grafts are used as substitutes for reconstruction of bone defects, the ingrowth of the implanted bon...

Journal: :Molecular cancer therapeutics 2009
Karen Y Dane Claudia Gottstein Patrick S Daugherty

Cancer heterogeneity renders risk stratification and therapy decisions challenging. Thus, genomic and proteomic methodologies have been used in an effort to identify biomarkers that can differentiate tumor subtypes to improve therapeutic outcome. Here, we report a generally applicable strategy to generate tumor type-specific peptide ligand arrays. Peptides that specifically recognize breast tum...

Journal: :Soft matter 2016
Patrick J S King M Giovanna Lizio Andrew Booth Richard F Collins Julie E Gough Aline F Miller Simon J Webb

Two complementary β-sheet-forming decapeptides have been created that form binary self-repairing hydrogels upon combination of the respective free-flowing peptide solutions at pH 7 and >0.28 wt%. The component peptides showed little structure separately but formed extended β-sheet fibres upon mixing, which became entangled to produce stiff hydrogels. Microscopy revealed two major structures; th...

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