This RFC is an official specification for the Internet community. It incorporates by reference, amends, corrects, and supplements the primary protocol standards documents relating to hosts. Distribution of this document is unlimited. Summary This is one RFC of a pair that defines and discusses the requirements for Internet host software. This RFC covers the communications protocol layers: link ...

Axial Flow Chromatography (AFC) is widely used for the purification of therapeutic Monoclonal Antibodies (MAbs). However, AFC columns can generate high pressure drops across the resin bed, preventing operation of the column at high flow rates especially at pilot or manufacturing-scales. Radial Flow Chromatography (RFC) was developed to provide lower pressure drops during chromatographic separat...

The development of collaborative control strategies for radiant cooling and ventilation systems improves thermal comfort energy efficiency. This study used the Transient System Simulation (TRNSYS) tool integrated with parametric simulation manager jEPlus to determine optimal starting operation mode a combined floor (RFC) system. results were validated by an experiment. optimization process was ...

Mostly Pointless Lamp Switching (MPLampS) is an architecture for carrying electricity over IP (with an MPLS control plane). According to our marketing department, MPLampS has the potential to dramatically lower the price, ease the distribution and usage, and improve the manageability of delivering electricity. This document is motivated by such work as SONET/SDH over IP/MPLS (with apologies to ...

This document specifies a method for transmission of IPv6 datagrams over the same medium as specified for IPv4 datagrams in RFC 1149. Status of This Memo This document is not an Internet Standards Track specification; it is published for informational purposes. This is a contribution to the RFC Series, independently of any other RFC stream. The RFC Editor has chosen to publish this document at ...

This document specifies a method for transmission of IPv6 datagrams over the same medium as specified for IPv4 datagrams in RFC 1149. Status of This Memo This document is not an Internet Standards Track specification; it is published for informational purposes. This is a contribution to the RFC Series, independently of any other RFC stream. The RFC Editor has chosen to publish this document at ...

The ever-elusive Null Packet received numerous mentions in documents in the RFC series, but it has never been explicitly defined. This memo corrects that omission. Status of This Memo This document is not an Internet Standards Track specification; it is published for informational purposes. This is a contribution to the RFC Series, independently of any other RFC stream. The RFC Editor has chose...

Folic acid deficiency during pregnancy causes birth neurocristopathic malformations resulting from aberrant development of neural crest cells. The Reduced folate carrier (RFC) is a membrane-bound receptor for facilitating transfer of reduced folate into the cells. RFC knockout mice are embryonic lethal and develop multiple malformations, including neurocristopathies. Here we show that XRFC is s...

Methotrexate (MTX) transport was examined in 27 patients with untreated acute lymphocytic leukemia (ALL) and 31 patients with relapsed ALL using a previously described fluorescent MTX analog (PT430) displacement assay (Blood 80:1158, 1992). Only 13% of untreated patients were considered to have impaired MTX transport, whereas more than 70% of relapsed patients had evidence of impaired MTX trans...

Background:Methotrexate is transported into the cell by the reduced folate carrier (RFC) and out of the cell by members of the multidrug resistance protein family (MRP). Transport proteins may affect the therapeutic efficacy of this drug in patients with rheumatoid arthritis. Objective: To investigate the potential benefit of the presence of RFC and the absence of functional MRP for the efficac...