This study examined children from an unselected birth cohort who had Wechsler Intelligence Scale for Children-Revised (WISC-R) verbal and performance IQ discrepancies that placed them beyond the 90th percentile. It was hypothesized that, relative to their cohort peers, these children would be characterized by greater frequency of perinatal difficulties, early childhood neurological abnormalitie...

BACKGROUND Duchenne muscular dystrophy (DMD) is a progressive muscle disorder associated with an intellectual deficit which is non-progressive. The aim of this study was to investigate brain microstructural changes in DMD and to explore the relationship between such changes and cognitive impairment. METHODS All participants (12 DMD patients, 14 age-matched healthy boys), intelligence quotient...

In a further follow-up study of the Cincinnati Lead Study Cohort, 253 children were administered the Wechsler Intelligence Scale for Children-Revised (WISC-R) at approximately 6.5 years of age. Postnatal blood lead concentrations were inversely associated with Full-Scale (FSIQ) and Performance IQ (PIQ). Following statistical adjustment for developmental co-factors such as maternal IQ and an ass...

OBJECTIVE The aim of the study was to investigate the associations between longitudinal sleep duration patterns and behavioral/cognitive functioning at school entry. DESIGN, SETTING, AND PARTICIPANTS Hyperactivity-impulsivity (HI), inattention, and daytime sleepiness scores were measured by questionnaire at 6 years of age in a sample of births from 1997 to 1998 in a Canadian province (N=1492)...