Giant cell tumor of soft tissue originally described in 1972 in two different series by Salm and Sissons is a rare entity, which is clinically and histopathologically indistinguishable from giant cell tumor of bone. Usually involve thigh, trunk, and lower extremities but rarely involve the hands. GCT-ST is a benign tumor, which can transform into malignant form and also has potential for recurr...

Giant cell tumor (GCT) of bone is a giant-cell-rich bony lesion associated with abundant multinucleated osteoclast-type giant cells. It is a primary neoplasm of bone with characteristic clinical, radiological, and pathological features. It is an expansive and lytic lesion without periosteal reaction and prominent peripheral sclerosis. Giant cells are also seen in other diseases like giant cell ...

1. Sanjay BK, Sim FH, Unni KK, McLeod RA, Klassen RA. Giant-cell tumours of the spine. J Bone Joint Surg Br. 1993;75:148—54. 2. Manjunatha HK, Ramaswamy AS, Sunil Kumar B. Aggressive giant cell tumor of the anterior arc of the rib. J Cytol. 2012;29:51—5. 3. Boriani S, Bandiera S, Casadei R, Boriani L, Bonthineni R, Gasbarrini A, et al. Giant cell tumor of the mobile spine. Spine. 2012;37:37—45....

Diffuse type tenosynovial giant cell tumor (D-TGCT) is a locally aggressive benign proliferation. Knee joint the most commonly affected site. We present case report with 16 months follow up after recurrent surgery and postoperative radiotherapy.

We describe the case of a 35 years old man with a nonspecific complaint of a slow growing solid mass in the frontal region. Radiological exams evidenced two more lesions : in the superior and lateral walls of the orbit. Treated with total excision of the lesions and a cranioplastic procedure at the same act, with favorable outcome. Microscopic findings suggested giant cell tumor in the three le...

BACKGROUND Multinucleated giant cell-containing tumors and pseudotumors of bone represent a heterogeneous group of benign and malignant lesions. Differential diagnosis can be challenging, particularly in instances of limited sampling. The purpose of this study was to evaluate the contribution of the P63 in the positive and differential diagnosis of giant cell tumor of bone. METHODS This study...