Objective(s): Integrons, as a potential element in the distribution and maintenance of drug resistance, have thoroughly been established. It is known that the high prevalence of integrons in multidrug-resistant (MDR) clinical isolates has become a serious public health concern. The objective of the present study was to determine the frequency of different classes of integrons in clinical isolat...

This introductory paper has two objectives. On the one hand, to present the guidelines of the evidence-based perspective on crime prevention as an alternative to the usual criminal policy, which often disregards conclusions based on scientific evidence. On the other hand, to discuss the contemporary situation in Spain regarding crime prevention and particularly the role psychology develops in t...

'If the clinician knows, or has good reason to believe, that a new therapy (A) is better than another therapy (B), he cannot participate in a comparative trial of therapy A versus therapy B. Ethically, the clinician is obligated to give therapy A to each new patient with a need for one of these therapies' (Shaw and Chalmers, 1970). This ethical dilemma would make participation in clinical trial...

service Email alerting top right corner of the article Receive free email alerts when new articles cite this article-sign up in the box at the Topic collections (368 articles) Systematic reviews (incl meta-analyses): examples (141 articles) Systematic reviews (incl meta-analyses): descriptions Articles on similar topics can be found in the following collections

background & aim : the number of cancer patients has been continuously increasing due to early diagnosis and the developments in cancer treatment. this has led to an increase in psychosocial problems associated with the diagnoses and treatment of cancer. loneliness is emphasized to be one of the most frequently observed psychological symptoms in cancer patients. personal and external factors th...

Over the last three decades, short- and long-term observational studies, clinical trials, systematic reviews, and meta-analyses have provided relevant information on the efficacy and safety of growth hormone (GH) replacement therapy in adults with GH deficiency (AGHD). The knowledge acquired during this time has been compiled into different guidelines that offer clinicians an evidence-based, pr...

Comparative trials that report binary outcome data are commonly pooled in systematic reviews and meta-analyses. This type of data can be presented as a series of 2-by-2 tables. The pooled odds ratio is often presented as the outcome of primary interest in the resulting meta-analysis. We examine the use of 7 models for random-effects meta-analyses that have been proposed for this purpose. The fi...

Systematic review and meta-analysis procedures make use of explicit methods to methodically search and critically appraise and synthesize the medical care research literature. The methods involve refining a clinical question, designing a search procedure to find eligible studies, and determining the validity of the eligible studies. Independent data extraction by two or more reviewers is prefer...

BACKGROUND Systematic reviews and meta-analyses on the incidence and prevalence of neurological conditions are important methods of quantifying the burden and risk of disease. METHODS The rigorous methodology required in order to minimize publication bias, account for study heterogeneity, and variation in study quality are described. When appropriate, a meta-analysis is a powerful statistical...