نتایج جستجو برای: respectively thus

تعداد نتایج: 1333259  

2013
F. Gregory Hayden Gregoly Hayden Josiah Royce Gregory Hayden

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1997
U Malmqvist K M Trybus S Yagi J Carmichael F S Fay

A key unanswered question in smooth muscle biology is whether phosphorylation of the myosin regulatory light chain (RLC) is sufficient for regulation of contraction, or if thin-filament-based regulatory systems also contribute to this process. To address this issue, the endogenous RLC was extracted from single smooth muscle cells and replaced with either a thiophosphorylated RLC or a mutant RLC...

2017
Jonathan Gotfried Rahul Kataria Ron Schey

The endocannabinoid system (ECS) primarily consists of cannabinoid receptors (CBRs), endogenous ligands, and enzymes for endocannabinoid biosynthesis and inactivation. Although the presence of CBRs, both CB1 and CB2, as well as a third receptor (G-protein receptor 55 [GPR55]), has been established in the gastrointestinal (GI) tract, few studies have focused on the role of cannabinoids on esopha...

Journal: :The EMBO journal 2004
Lia Baki Junichi Shioi Paul Wen Zhiping Shao Alexander Schwarzman Miguel Gama-Sosa Rachael Neve Nikolaos K Robakis

Phosphatidylinositol 3-kinase (PI3K) promotes cell survival and communication by activating its downstream effector Akt kinase. Here we show that PS1, a protein involved in familial Alzheimer's disease (FAD), promotes cell survival by activating the PI3K/Akt cell survival signaling. This function of PS1 is unaffected by gamma-secretase inhibitors. Pharmacological and genetic evidence indicates ...

2017
Andreas Happe Bob Duncan Alfred Bratterud

Unikernels allow application deployment through custom-built minimal virtual machines. The authors investigate how unikernels and their inherent minimalism benefit system security. The analysis starts with common security vulnerability classes and their possible remediation. A platonic unikernel framework is used to describe how unikernels can solve common security problems, focusing both on a ...

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