Vancomycin monotherapy of deep-seated staphylococcal infection may be associated with poor bacteriological response. We evaluated 24 unique patient isolates of methicillin-resistant Staphylococcus aureus (MRSA) for vancomycin-gentamicin synergism by determining time-kill curves for vancomycin at 10 micrograms/ml and gentamicin at 1 microgram/ml. Nine MRSA strains showed high-level gentamicin re...

In this study, we aimed to compare the antibacterial activities of daptomycin and vancomycin in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) meningitis (induced by MRSA strain ATCC 43300) in an experimental rabbit meningitis model. After an 8-h period of treatment, bacterial counts decreased significantly in both treatment groups compared to the control group (P < 0.05). ...

LEARNING OBJECTIVES : After studying this article, the participant should be able to: 1. Identify risk factors associated with community-acquired methicillin-resistant Staphylococcus aureus. 2. Recognize the clinical presentation of patients with community-acquired methicillin-resistant S. aureus. 3. Understand the treatment and indications for decolonization of patients who have community-acqu...

Background Active Bacterial Core surveillance (ABCs) is a core component of the Emerging Infections Program (EIP) Network sponsored by the Centers for Disease Control and Prevention (CDC). The purpose of ABCs is to determine the incidence and epidemiologic characteristics of invasive disease due to Haemophilus influenzae, Neisseria meningitidis, group A Streptococcus (GAS), group B Streptococcu...

Our three-hospital system began active surveillance for methicillin-resistant Staphylococcus aureus (MRSA) nasal colonization, with decolonization of positive patients, on all admissions starting 1 August 2005. A question not previously addressed is whether reduction of the incidence of MRSA disease would lower the total number of S. aureus clinical isolates recovered by the microbiology labora...

Daptomycin is inactivated by pulmonary surfactant, but its effectiveness in hematogenous pulmonary infection has been poorly studied. The potential therapeutic application was evaluated in a methicillin-resistant Staphylococcus aureus (MRSA) hematogenous pulmonary infection mouse model. Compared with control results, daptomycin improved survival (P < 0.001) and decreased the number of abscesses...

A multicenter preclinical evaluation was conducted to evaluate the performance of two Cepheid Xpert assays for detection of methicillin-resistant Staphylococcus aureus (MRSA) and S. aureus. Sensitivity was 97.1% and 98.3% for MRSA in wound and blood culture specimens, respectively. Sensitivity was 100% for S. aureus from both specimen types.

Staphylococcal infection is of major importance in both Human and Animals. Some staphylococcal bacteria are Methicillin-resistant. This paper reviews the current information on Methicillin-Resistant Staphylococcus aureus (MRSA) in dogs and cats. Staphylococcus aureus is a Gram positive, non-spore forming coccus. It may be found singly, in pairs, in short chains, or in irregular clusters. The co...

conclusions more than a quarter of the strains harboured sccmec type i. staphylococcus aureus isolates were clustered into eight predominant pfge pulsotypes. the current study should be considered preliminary and further use of molecular studies to monitor the epidemiology of mrsa and its evolution is highly recommended. materials and methods dna was extracted from 114 frozen s. aureus strains ...

Methicillin resistant Staphylococcus aureus has become an enormous problem for health care providers because it is hard to treat and is sometimes called super bug. Early and accurate detection of methicillin resistance in Staphylococcus aureus is essential for the treatment of overt infections and the implementation of infection control practices. The phenotypic detection of mecA-mediated resis...