Nosocomial infection by multi-drug resistant bacteria (MDR) e.g: extended-spectrumBeta-lactamase(ESBL) producing Enterobacteriaceae, Acinetobacter baumannii and carbapenem-resistant Enterobacteriaceae (CRE) is increased worldwide, with major burden due to limited choices of antibiotics (Peleg & Hooper, 2010, Magiorakos et al.,2012). Tigecycline (TIG) and Colistin (COL) are examples of the few d...

Antibiotic resistance is a global challenge that impacts all pharmaceutically used antibiotics. The origin of the genes associated with this resistance is of significant importance to our understanding of the evolution and dissemination of antibiotic resistance in pathogens. A growing body of evidence implicates environmental organisms as reservoirs of these resistance genes; however, the role ...

Enterococci have emerged as significant nosocomial pathogens. Enterococci with resistance to commonly used antibiotics are appearing more frequently. We encountered at our institution several infections caused by Enterococcus faecium with high-level resistance to ampicillin, vancomycin, and gentamicin. The optimal antibiotic therapy for serious infections with unusually resistant enterococci ha...

A ntimicrobial resistance (AMR) and the spread of multidrug resistant bacteria is a global patient safety problem and a major public health concern. In India, as elsewhere in South East Asia, many interlinked factors—including overuse of antibiotics, limited clinical diagnostic and laboratory capacity, and poor infection control, hygiene, and sanitation—have contributed to the emergence and spr...

OBJECTIVE To describe antimicrobial resistance patterns for healthcare-associated infections (HAIs) reported to the National Healthcare Safety Network (NHSN) during 2009-2010. METHODS Central line-associated bloodstream infections, catheter-associated urinary tract infections, ventilator-associated pneumonia, and surgical site infections were included. Pooled mean proportions of isolates inte...

The increase in geographical areas used for cultivation of transgenic glyphosate herbicide-resistant cotton has hindered the stalk destruction, compromised phytosanitary break implementation and consequently increased population insect pests plant pathogens. This study evaluated efficiency combining mechanical chemical methods destruction resistant to herbicide. Two experiments were carried out...

Despite regular disinfection and decontamination of the hospital floors and surfaces, resistant pathogens from the hospital surfaces and their transmission to humans have been reported recently. The resistance of pathogens to the disinfectant agents or failed disinfection techniques have put the routine floor and non-critical surface disinfection done in hospitals into question with regard to t...

Mathematical models predict that the future of epidemics of drug-resistant pathogens depends in part on the competitive fitness of drug-resistant strains. Considering metacyclogenesis (differentiation process essential for infectivity) as a major contributor to the fitness of Leishmania donovani, we tested its relationship with pentavalent antimony (SbV) resistance in clinical lines. Different ...

BACKGROUND Urinary tract pathogens obtained from patients in Madagascar are becoming increasingly resistant to commonly used antibiotics that are readily available at a low price. This poses a real problem for the treatment of community-acquired urinary tract infections (UTIs) in Madagascar. OBJECTIVES To obtain data on the pathogens responsible for community-acquired UTIs in Antananarivo and...

Daptomycin is a novel cyclic lipopeptide antibiotic that provides rapid bactericidal activity against gram-positive pathogens in vitro, including methicillin-susceptible Staphylococcus aureus, methicillin-resistant S. aureus, vancomycin-resistant S. aureus, penicillin-resistant Streptococcus pneumoniae, and ampicillin- and vancomycin-resistant enterococci. The United States Food and Drug Admini...