Xeroderma Pigmentosum protein C (XPC) is involved in recognition and repair of bulky DNA damage such as lesions induced by Ultra Violet (UV) radiation. XPC-mutated cells are, therefore, photosensitive accumulate UVB-induced pyrimidine dimers leading to increased cancer incidence. Here, we performed a high-throughput screen identify chemicals capable normalizing the XP-C phenotype (hyper-photose...

is a group of chemicals, including nitrogen mustards, acridines, nitroT::gnidine, azaserine, nitrofurazone, mitomycin, nitrous acid, and 2-aminopurine, which, despite their diverse chemical or physical properties (see review by FREESE, 1963), share many biological properties among themselves and with ultraviolet radiation (UV) in affecting microorganisms. They are mutagenic; several of them ind...

D epending on which statistics you read, the estimates for North America for health care-acquired infections (HCAI) range from a low of 490,000 cases of infections caused by health care practices to more than 1.7 million a year. Anywhere from 48,000 to 100,000 fatalities annually can be tracked back to the development of infections in patients who did not have an infection upon admission. Beyon...

The toxicology of synthetic chemicals is compared to that of natural chemicals, which represent the vast bulk of the chemicals to which humans are exposed. It is argued that animals have a broad array of inducible general defenses to combat the changing array of toxic chemicals in plant food (nature's pesticides) and that these defenses are effective against both natural and synthetic toxins. S...

Treated sea water is the most significant source of water and surfactant floods. The various chemicals employed in treatment plants should be compatible with surfactant systems. Based on surface tension experiments, the activity of these chemicals is examined over a wide range of concentrations in different solutions, including distillated water, sea water by using three types of surfactant mix...

There are several agrochemicals to control Botrytis cinerea, the causal agent for gray mold in grapes, and new ones are being developed. The fungicides used to control Botrytis in vineyards of the Champagne are presented together with some of their deleterious effects on non-target species. Until recently, fungicides basically belonged to three groups: the carbamates, the benzimidazoles, and th...

Neurogenic inflammation as a pathway distinct from antigen-driven, immune-mediated inflammation may play a pivotal role in understanding a broad class of environmental health problems resulting from chemical exposures. Recent progress in understanding the mediators, triggers, and regulation of neurogenic inflammation is reviewed. Evidence for and speculations about a role for neurogenic inflamm...

methods for measuring toxicity or respiratory activity of microbial cultures can be used as tools for assessing the presence of chemicals and their impact on the streams. the proposed toxicity test is based on the respirometric characteristics of the bacteria according to the principals of biolog’s microplate system. as the microorganism are utilizing the carbon source (peptone), the reductio...

We show that vapors of different chemicals produce distinguishably different effects on the low-frequency noise spectra of graphene. It was found in a systematic study that some gases change the electrical resistance of graphene devices without changing their low-frequency noise spectra while other gases modify the noise spectra by inducing Lorentzian components with distinctive features. The c...