Despite many years of potent antiretroviral therapy, latently infected cells and low levels of plasma virus have been found to persist in HIV-infected patients. The factors influencing this persistence and their relative contributions have not been fully elucidated and remain controversial. Here, we address these issues by developing and employing a simple, but mechanistic viral dynamics model....

Zoonotic pathogens that cause devastating morbidity and mortality in humans may be relatively harmless in their natural reservoir hosts. The tick-borne bacterium Borrelia burgdorferi causes Lyme disease in humans but few studies have investigated whether this pathogen reduces the fitness of its reservoir hosts under natural conditions. We analyzed four years of capture-mark-recapture (CMR) data...

extra-intestinal pathogenic escherichia coli (expec) strains are divided into uropathogenic e. coli (upec), strains causing neonatal meningitis and septicaemic e. coli. the most common pathotype of expec is found among patients with urinary tract infection (uti), defined as upec. these bacteria are responsible for >90% of cases of uti and are often found amongst the faecal flora of the same hos...

through a collection of cooperative agents called ants, the near optimal solution to the multi-reservoir operation problem may be effectively achieved employing ant colony optimization algorithms (acoas). the problem is approached by considering a finite operating horizon, classifying the possible releases from the reservoir(s) into pre-determined intervals, and projecting the problem on a grap...

This study describes the molecular typing of Pneumocystis jiroveci organisms from 5 nonpremature immunocompetent infants who developed a primary infection. Four P. jiroveci internal transcribed spacer (ITS) types were identified. All have been previously described in reports concerning immunosuppressed adults with pneumocystosis. Present data suggest that identical types can be implicated eithe...