in this study which was carried out in 1974 in the province of isphahan a total of 23,273 individuals in the cities, and 18,671 individuals in the villages of the same area were studied. results show that the median age in rural area is 16 and in urban area is 18 years. the birth rate in rural is 27.7 per thousand were as the same rate in urban area is 40.2 per thousand. similarly the general f...

The endosomal sorting complexes required for transport (ESCRT) drive multivesicular body (MVB) biogenesis and cytokinetic abscission. Originally identified through genetics and cell biology, more recent work has begun to elucidate the molecular mechanisms of ESCRT-mediated membrane remodeling, with special focus on the ESCRT-III complex. In particular, several light and electron microscopic stu...

Miriam Getz is with the Kibuzzim College of Education, Tel Aviv, Israel and the Israel Sport Center for the Disabled in Ramat Gan, Israel. E-mail: [email protected]. Yeshayahu Hutzler is with Zinman College for Physical Education and Sports at the Wingate Institute and the Israel Sport Center for the Disabled Ramat Gan, Israel. E-mail: [email protected]. Adri Vermeer is with the faculty of ...

EhADH112 is an Entamoeba histolytica Bro1 domain-containing protein, structurally related to mammalian ALIX and yeast BRO1, both involved in the Endosomal Sorting Complexes Required for Transport (ESCRT)-mediated multivesicular bodies (MVB) biogenesis. Here, we investigated an alternative role for EhADH112 in the MVB protein trafficking pathway by overexpressing 166 amino acids of its N-termina...

In this paper, it is argued that 'coreference an-notation', as currently performed in the MUC community, goes well beyond annotation of the relation of coreference as it is commonly understood. As a result, it is not always clear what semantic relation these annotations are actually encoding. The paper discusses a number of interrelated problems with coreference annotation and concludes that re...

Retroviruses have evolved a mechanism for the release of particles from the cell membrane that appropriates cellular protein complexes, referred to as ESCRT-I, -II, -III, normally involved in the biogenesis of multivesicular bodies. Three different classes of late assembly (L) domains encoded in Gag, with core sequences of PPXY, PTAP, and YPXL, recruit different components of the ESCRT machiner...

The first thing to note about these principles is that (as I will be understanding them), they are not merely classificatory principles for demarcating/separating cases of knowledge from non-knowledge. As I will be understanding (and using) them, (C) and (CC) are intended to be featured in epistemological explanations of why some agent S knows that Q (as opposed, e.g., to merely truly believing...

Targeting of ubiquitylated transmembrane proteins into luminal vesicles of endosomal multivesicular bodies (MVBs) depends on their recognition by endosomal sorting complexes required for transport (ESCRTs), which are also required for MVB vesicle formation. The model originally proposed for how ESCRTs function succinctly summarizes much of the protein-protein interaction and genetic data but ov...

Endosomes and autophagosomes are two vesicular compartments involved in the degradation and recycling of cellular material. They both undergo a maturation process and finally fuse with the lysosome. In mammals, the convergence between endosomes and autophagosomes is a multistep process that can generate intermediate vesicles named amphisomes. Using knockdowns and mutants of the ESCRT machinery ...