A series of studies to further evaluate the developmental and reproductive toxicity of inhaled 1,3-butadiene was sponsored by the National Toxicology Program. Pregnant Sprague-Dawley rats (24-28/group) and Swiss (CD-1) mice (18-22/group) were exposed to atmospheric concentrations of 0, 40, 200, or 1000 ppm 1,3-butadiene for 6 hr/day on days 6 through 15 of gestation (dg) and killed on dg 18 (mi...

1,3-Butadiene (CAS No. 106-99-0) meets the criteria for listing under Proposition 65 via the authoritative bodies listing mechanism as known to the State to cause reproductive toxicity (developmental, male reproductive and female reproductive endpoints). The regulatory guidance for listing by this mechanism is set forth in Title 22, California Code of Regulations (CCR), Section 12306. For examp...

Panax ginseng is known to potentiate the immune system via its antioxidant properties. Cadmium as an environmental pollutant has destructive effects on body organs especially reproductive system. This study investigated of P. extract against cadmium-induced testicular toxicity in rats. In this experimental study, 50 male adult rats were randomly divided into 5 groups: A significant decrease was...

: Apical tests for reproductive or developmental toxicity assess the potential for a compound to affect any of the thousands of steps involved in making gametes and in the successful development of a fully functional offspring. Conventionally, this is thought to require at least 21 days for rodent female reproduction and for development, and close to 70 days for spermatogenesis. Short-term test...

Acute, subacute, and chronic toxicity studies, carcinogenicity bioassays, and reproductive and genetic toxicology studies were performed with quinapril, an ACE inhibitor used in the treatment of hypertension. Acute toxicity is minimal in rodents, and repeated dosing elicits gastric irritation, juxtaglomerular apparatus (JGA) hypertrophy and hyperplasia and tubular degenerative changes in the ki...

objective: the main objective of the current study was to observe the ameliorative effect of withania somnifera on arsenic-induced testicular toxicity by exploring the crucial parameters such as sperm counts, sperm motility, hormonal assay and lipid peroxidation including histopathology. materials and methods: in the present study, arsenic in the form of sodium arsenite was administered orally ...

In 2009 the Brazilian Ministry of Health published a document named RENISUS that lists 71 herbs traditionally used in Brazil that could result in phytomedicines to be dispensed by the governmental health care program. This manuscript reviews female reproductive and/or developmental toxicity information of these herbs. More than half (35) of the herbs lack information regarding female reproducti...