Downlo roRNAs (miRNA), a class of natural RNA-interfering agents, have recently been identified as attractive s for therapeutic intervention. The rationale for developing miRNA therapeutics is based on the premise berrantly expressed miRNAs play key roles in the development of human disease, and that correcting miRNA deficiencies by either antagonizing or restoring miRNA function may provide a ...

In the historical period it was commonly held that estrogen had two principal benefits to postmenopausal women: 1) To alleviate the constitutional symptoms related to the climacteric such as vasomotor symptoms (hot flushes), night sweats, somnolence, and vaginal dryness; and, 2.) To work in concert with weight-bearing exercise and diet replete with calcium to decrease or minimize their role in ...

During the follow-up of 224 cases of treated hypothyroidism, 14 clinically euthyroid patients were found to have elevated serum thyrotrophin and normal total thyroxine concentrations. Closer observation of these patients during the following 27 months resulted in the serum thyrotrophin levels returning to normal spontaneously in 8 patients (Group 1) whilst remaining elevated in 6 (Group 2), des...

In spite of the fact that smoking is the main cause of obstetric morbidity and mortality, 20% of North American women smoke during pregnancy. In Spain, this figure is as high as 30% to 35%. Treating smoking addiction in these patients should be the first and most important therapeutic measure undertaken by health professionals responsible for the care of pregnant women. All experts recommend th...

There are significant ethnic variations in the incidence of kidney disease. White European populations appear to be uniquely protected compared to increased incidences of end-stage renal disease in indigenous and migrant ethnic minority populations. This increase is partly explained by a high prevalence of diabetic nephropathy, but there is also an increased susceptibility to a range of other r...