INTRODUCTION AND OBJECTIVES Sprint Fidelis defibrillation leads are prone to early failure. Most of the reported series come from a single institution. This paper describes the clinical experience in nine Spanish hospitals. METHODS Clinical, implant, and follow-up data of all patients with a Sprint Fidelis lead were analyzed. All cases of lead failure were identified, medium-term lead surviva...

Mining gene-expression-profiling data identified a novel gene that is specifically expressed in preimplantation embryos. Hmgpi, a putative chromosomal protein with two high-mobility-group boxes, is zygotically transcribed during zygotic genome activation, but is not transcribed postimplantation. The Hmgpi-encoded protein (HMGPI), first detected at the 4-cell stage, remains highly expressed in p...

BACKGROUND AND AIM To establish whether left ventricular (LV) pacing by mini-thoracotomy is a safe and feasible procedure after failed transvenous cardiac resynchronisation therapy (CRT), we described four cases of patients who demonstrated congestive heart failure (CHF), had transvenous LV lead implantation failures, and underwent a mini-left-lateral thoracotomy and implantation of an epicardi...

BACKGROUND The optimal treatment for cartilage lesions has not yet been established. The objective of this randomized trial was to compare autologous chondrocyte implantation with microfracture. This paper represents an update, with presentation of the clinical results at five years. METHODS Eighty patients who had a single chronic symptomatic cartilage defect on the femoral condyle in a stab...

BACKGROUND One in six couples suffer from infertility problems requiring in vitro fertilization therapy; however, the average birth rates in the past decade per IVF-embryo transfer cycle have remained static at around 25%. Although implantation failure is considered a major cause of infertility in otherwise healthy women, inadequate uterine receptivity is considered to be responsible for only t...

Three groups of chronic, skull-anchored, percutaneous implants differing in materials, design and surgical procedures used for implantation, were tested in macaque monkeys in conjunction with studies of an inner ear stimulation device. Implants from the first two groups in which high-speed drilling methods and stainless steel materials were used, showed a high percentage of failures during the ...

INTRODUCTION: The AGILITY (DePuy, Warsaw, IN) total ankle arthroplasty (TAA) system was introduced in response to the high failure rates associated with the first generation of total ankle arthroplasty. First generation failures were generally attributed to increased loads across cement-bone interface, increased bone resection and poor surgical technique. Advancements in product design have in...

Co-cultures of human embryos, particularly with Vero cells, are used by several French groups, mainly in cases of successive failures of implantation. In most cases co-culture is continued until the blastocyst stage, expanded if possible. A total of 1603 co-cultures have been performed by 11 groups over a 2-year period. Of these, 41.8% of cleaved eggs (day 2) reached the blastocyst stage at day...

Purpose To report the outcomes of implantation of the Boston Type I keratoprosthesis in three patients with Acanthamoeba keratitis (AK), a severe infection that can lead to significant visual loss. Observations Case series reporting three patients with difficult cases of AK that needed multiple corneal transplantations and glaucoma surgeries. All patients were implanted with the Boston Type I...

Objective: Repeated implantation failure (RIF) is a condition in which the embryos implantation decreases in the endometrium. So, our aim was to evaluate the effect of local endometrial injury on embryo transfer results. Materials and methods: In this simple randomized clinical trial (RCT), a total of 120 patients were selected. The participants were less than 40 years old, and they are in thei...