We present a new preclinical model to study treatment, resolution and sequelae of severe ascending pyelonephritis. Urinary tract infection (UTI), primarily caused by uropathogenic Escherichia coli (UPEC), is a common disease in children. Severe pyelonephritis is the primary cause of acquired renal scarring in childhood, which may eventually lead to hypertension and chronic kidney disease in a s...

This paper reviews current concepts regarding the pathophysiology, diagnostic evaluation, and treatment of microalbuminuria and proteinuria in adults. Microalbuminuria (in diabetics) and proteinuria are early markers for potentially serious renal disease, and are associated with increased risk of atherosclerotic cardiovascular disease. Proteinuria also contributes to renal scarring, and acceler...

1. Hematogenous E. coli pyelonephritis was produced in rats. The localization of the organisms and the persistence of bacterial antigens was followed by fluorescent antibody techniques as well as by standard histological and bacteriological methods. 2. Salient sequential features were as follows: Single organisms passed through vessel walls into the renal interstitium and began multiplication a...

Progressive renal disease is associated with the development of fibrosing lesions in the glomerulusglomerulosclerosis, and in the interstitiuminterstitial fibrosis. The mechanisms involved in this processes are shared by the inflammatory cells and the resident cells: glomerular mesangial cell, interstitial fibroblast, tubular epithelial cell and vascular smooth muscle cell. These resident cells...

The extent of renal scarring in chronic kidney disease (CKD) can only be ascertained by highly invasive, painful and sometimes risky tissue biopsy. Interestingly, CKD-related abnormalities in kidney size can often be visualized using ultrasound. Nevertheless, not only does the ellipsoid formula used today underestimate true renal size but also the relation governing renal size and collagen cont...

abstract background: experience with vesicoureteral reflux (vur) differs in different centers and there are plenty of controversies. the aim of this study was to evaluate the outcome of primary vur complications and the rate of recurrence of uti. methods: the medical charts of all infants and children with primary vur who were followed up by two nephrologists were reviewed. during 19 years (198...

background: experience with vesicoureteral reflux (vur) differs in different centers and there is plenty of controversies. objective: to evaluate the outcome of primary vur complications and the rate of recurrence of uti. methods:   in a retrospective study, the medical charts of all infants and children with primary vur who were followed up by one nephrologist were reviewed.  during 16 years, ...

The main reason for investigation of UTI is to ensure early identification of urological pathology, which, if left untreated, may lead to ESRD [6-9]. Internationally in developed countries, CAKUT and hereditary nephropathies account up to 66% of all cases of CKD [6]. The situation is similar in Jamaica where CAKUT accounts for 41-44% of cases of CRF [7,8]. Posterior urethral valves are the most...