BACKGROUND The main purpose of this study was to examine histopathological changes seen in renal biopsies from patients with Wegener's granulomatosis (WG) with varying degrees of renal involvement and to study possible correlations between the morphological variables and the severity of the disease. METHODS Ninety-four patients with WG and active renal disease were included in this retrospect...

BACKGROUND The aim of this study was to evaluate the clinical characteristics of nondiabetic nephropathy in type 2 diabetes mellitus patients and to find a clinical significance of renal biopsy and immunosuppressive treatment in such a patient. METHODS Renal biopsy results, clinical parameters, and renal outcomes were analyzed in 75 diabetic patients who underwent kidney biopsy at Chungnam Na...

Renal biopsy remains the "gold standard" for the diagnosis of renal allograft dysfunction. The aim of our study was to highlight the importance of renal biopsy in the management of allograft dysfunction (early diagnosis and therapeutic approach). Our study included 23 renal allograft biopsies from 20 patients. This retrospective study analyzed the demographic and clinical data, histological res...

Sarcoidosis is a systemic disease with multiorgan involvement which can cause renal failure through several different mechanisms. Granulomatous interstitial nephritis is an important albeit less frequent cause of clinically significant renal disease. Herein, we present the case of a 46 year old woman with a history of sarcoidosis whom we evaluated for rapidly worsening kidney function and prote...

Background: Regulatory T cells have been suggested to have a protective role against acute rejection in allograft recipients. However, there is little information available about their contribution to chronic rejection process. The role of transforming growth factor-beta 1 (TGF- β1) as a profibrogenic and/or immunoregulatory cytokine in renal allografts is also controversial. Objectives: To eva...

In this first report on the experience with renal transplantation in children and adolescents in southern Iran during the past five years, thirty-two patients (aged 5- 19 years old 18 males, 14 females) received renal allografts. Pretransplantation pathologic diagnoses by kidney biopsy were: membranoproliferative glomerulonephritis (MPGN), rapidly progressive glomerulonephritis (RPGN), chr...

To the Editor: The percutaneous renal biopsy is an essential tool in the diagnosis and evaluation of kidney disease. Most renal biopsies are performed under direct ultrasound guidance with automated biopsy needles, techniques that have substantially reduced the risks of the procedure. However, the kidney biopsy still carries a considerable risk of bleeding complications. Although certain risk f...

A 74-year old man with complaints of malaise was diagnosed with acute renal failure of unknown cause and was referred to our outpatient clinic because of bluish-red maculae in a reticular pattern on his forefeet and toes of unclear duration. Six weeks prior to the onset of his general symptoms he had undergone an endovascular aorta repair (EVAR) procedure. A lesional skin biopsy was taken and r...

Enteric hyperoxaluria, a complication of jejuno-ileal bypass, is associated with renal failure owing to oxalate nephrosis or tubulo-interstitial nephritis. A 54 year old woman developed renal failure 17 months after jejuno-ileal bypass for morbid obesity. Renal biopsy showed widespread acute on chronic damage to the tubulo-interstitial compartment with extensive deposition of oxalate crystals. ...

PURPOSE To evaluate the efficacy of needle biopsy for diagnosing Wilms tumor (WT) before chemotherapy. MATERIALS AND METHODS We reviewed our institutional experience with Tru-Cut biopsy of pediatric renal masses in patients who subsequently underwent nephrectomy. We compared biopsy pathology with nephrectomy specimens to determine if biopsy accurately predicted final pathology. RESULTS Seve...