BACKGROUND Early suppression of disease activity in (rheumatoid) arthritis (RA) patients may result in drug-free remission and prevent damage. We assessed 2-year clinical and radiological outcomes of two disease activity score (DAS)-remission-steered treatment strategies in early arthritis patients. METHODS Patients (n = 610) with early RA or undifferentiated arthritis (UA) were treated with ...

An analysis of two protocols transcranial magnetic stimulation (TMS) for treatment‐resistant depression has found that remission rates were higher in older‐adult patients who had undergone fewer unsuccessful medication trials. Remission lowest with three or more antidepressant Results published online June 19, 2023, The British Journal Psychiatry .

Remission in randomized clinical trials The FIN-RACo study was the first randomized controlled rheumatoid arthritis (RA) trial that used remission as the primary outcome measure [1]. In the FIN-RACo trial, remission was defined as the treatment goal and the primary outcome measure as early as 1993, years before the first biologic agent became available. Results of FIN-RACo were amazing: 42% of ...

Background A recent meta-analysis by Ferreira et al. (2020) has questioned the validity of using Patient Global Assessment (PGA) to define remission in Boolean criteria (4-variable remission, 4vR) [1]. This is because PGA, which presumptively reflects a patient’s perception disease activity, influenced both inflammatory and non-inflammatory mechanisms, thus questioning PGA-related definitions w...

BACKGROUND Remission is arguably the ultimate therapeutic goal in rheumatoid arthritis (RA). Applying modern strategies, clinical remission can be achieved in a substantial number of patients with early RA (ERA). Even in those patients, the number and scope of erosions can increase. We, therefore, investigated the value of MRI for the detection of radiological progression in patients with DAS28...

BACKGROUND Evidence on the role of plasma exchange for treating recurrent post-transplant focal segmental glomerulosclerosis (FSGS) comes largely from individual cases and uncontrolled series. We conducted a systematic review and meta-analysis to estimate the remission rate after treatment with plasma exchange, and to determine if remission varied with patient or treatment characteristics. ME...

INTRODUCTION The aim of this study was to investigate patient reported outcomes (PROs) of functional ability and health related quality of life (HRQoL) in patients with early (rheumatoid) arthritis during one year of remission steered treatment. METHODS In this study, 610 patients with early rheumatoid arthritis (RA) or undifferentiated arthritis (UA) were treated with methotrexate (MTX) and ...

AIMS The comparative efficacy of Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy on Type 2 diabetes remission and the role of weight loss are unclear. The DiaRem diabetes remission prediction score uses HbA1c , age and diabetes medications but not diabetes duration. The aim of this study was to compare the DiaRem with the DiaBetter score that includes diabetes duration, upon combined (co...

Nonalcoholic fatty liver disease (NAFLD) is a common chronic disease that is associated with high serum uric acid (SUA) levels, although the effects of high SUA levels on NAFLD remission remain unclear. In addition, it is unclear whether obesity and high SUA levels have a combined effect on NAFLD remission. This retrospective cohort study evaluated male employees of seven Chinese companies and ...

-Peripheral blood leucocytes from chronic myeloid leukaemia patients in remission were tested for inhibition of migration in presence of solubilized membrane antigens from leukaemic cells in 15 cases. Eight out of 9 autochthonous combinations (88*8%) and 35/49 allogeneic combinations (7144%) showed inhibition of migration. Antigens prepared from relapse leukaemic cell samples in 4 cases showed ...