In this study, it is aimed to produce composite hydroxyapatite (HA) gelatin microspheres (HA-Gel) intended for drug delivery applications. The polymer network within the HA particle-matrix can be facilitated as a carrier system. dissolution of in physiological medium allows release controlled manner and also develop cell-microsphere interactions. Gelatin functionalized bare granules were produc...

Engineered microsphere possesses the advantage of strong light manipulation at sub-wavelength scale and emerges as a promising candidate to shrink the focal spot size. Here we demonstrated a center-covered engineered microsphere which can adjust the transverse component of the incident beam and achieve a sharp photonic nanojet. Modification of the beam width and working distance of the photonic...

The formulation and characterization of gentamicin-loaded microspheres as a delivery system targeting enterotoxigenic Escherichia coli K88 (E. coli K88) was investigated. Glycated albumin with lactose (BSA-glucose-β (4-1) galactose) was used as the microsphere matrix (MS-Lac) and gentamicin included as the transported antibiotic. The proposed target strategy was that exposed galactoses of MS-La...

To minimize the unwanted toxic effects of anti maniac drug lithium carbonate by kinetic control of drug release, it was entrapped into gastro resistant, biodegradable, waxes and fat such as beeswax, cetostearyl alcohol, spermaceti and cetylalcohol microspheres using meltable emulsified dispersion cooling induced solidification technique utilizing a wetting agent. Solid, discrete, reproducible f...

Monoclonal antibodies are therapeutic molecules known for their high specificity and versatility in the treatment of cancer autoimmune disorders, but dosage forms typically limited to low concentrations large fluid volumes due formulation challenges. Hydrogel microsphere formulations offer a route quicker, patient-friendly dosing regimens monoclonal with loading favorable flow properties needed...

The mixing required for post-mould gelatinisation of syntactic foams using starch as binder was studied. It was found that starch particles tend to adhere to hollow microspheres during mixing, forming agglomerates. A transition in the buoyancy of microsphere-starch phases was found at a particular volume fraction of starch. The transitional point was close to a volume fraction of starch at whic...

The aim of the study was to prepare site specific drug delivery of naproxen sodium using sodium alginate and Eudragit S-100 as a mucoadhesive and pH-sensitive polymer, respectively. Core microspheres of alginate were prepared by a modified emulsification method followed by cross-linking with CaCl2, which was further coated with the pH dependent polymer Eudragit S-100 (2.5 or 5 %) to prevent dru...

Objective. To determine whether several topical compounds and other chemical entities are able to diminish the surface hydrophobicity of yeast cells. Method. Hydrophobicity of yeast cells was determined by binding styrene microspheres to the surface of untreated yeast or yeast pre-incubated with various substances with potential for cell surface modification. The degree of microsphere adherence...

Purpose: To prepare and evaluate metformin microspheres for prolonged release. Methods: Metformin microspheres were prepared by non-aqueous solvent evaporation method using various polymers, including ethylcellulose (EC), hydroxypropyl methylcellulose (HPMC), carbopol 934P (CA) and chitosan (CH). The effect of process variables, viz, drug/polymer ratio, stirring rate and type of polymer on the ...

Design and construction of biocompatible tissue-engineered stents for long segment peripheral nerve regeneration has become a significant research topic. However, in the early of damaged, the immigration and aggregation of inflammatory cells and factors can induce a secondary nerve injury and peroxide damage to the injured nerves, which in turn can result in severe neuronal apoptosis. The use o...