The aim of this study was to prepare dry powder inhalers (DPIs) containing amphotericin B-loaded solid lipid nanoparticles (AMB-SLNs) as an alternative approach for prevention of pulmonary aspergillosis. For solubilizing AMB in small amounts of organic solvents ion paired complexes were firstly formed by establishing electrostatic interaction between AMB and distearoyl phosphatidylglycerol (DSP...

OBJECTIVE To determine if a dual-purpose bone graft can regenerate bone and reduce infection in highly contaminated bone critical size defects in rats. METHODS Biodegradable polyurethane (PUR) scaffolds were loaded with recombinant human bone morphogenetic protein-2 (BMP-2) and vancomycin (Vanc). The release kinetics of the BMP-2 were tuned to take advantage of its mechanism of action (ie, an...

Controlled release urea (CRU) is considered to enhance crop yields while alleviating negative environmental problems caused by the hazardous gas emissions that are associated with high concentrations of ammonium (NH₄⁺) and nitrate (NO₃-) in black soils. Short-term effects of sulfur-coated urea (SCU) and polyurethane-coated urea (PCU), compared with conventional urea, on NO₃- and NH₄⁺ in black s...

The aim of the present study is to investigate the effect of Ammonio Methacrylate Copolymer Type B (Eudragit RS 30 D) on the release kinetics study of diclofenac sodium form coated pellets. The effect of the incorporation of xanthan gum into the coating formulation was also the goal of this study. Eudragit RS 30 D and xanthan gum was added into the formulation at 5:1 ratio. Different percent of...

The determination of in vitro release kinetics of peptides from poly(D,Llactide-co-glyolide) (PLGA) microspheres generally requires optimization of the test conditions for a given formulation. This is particularly important when in vitro/in vivo correlation should be determined. Here, the somatostatin analogue vapreotide pamoate, an octapeptide, was microencapsulated into PLGA 50:50 by spray-dr...

Mammalian KIF3AB is an N-terminal processive kinesin-2 that is best known for its roles in intracellular transport. There has been significant interest in KIF3AB to define the key principles that underlie its processivity but also to define the mechanistic basis of its sensitivity to force. In this study, the kinetics for entry into the processive run were quantified. The results show for KIF3A...

Characterization and Evaluation of the Release Kinetics a Model Poorly Water-Soluble Low Dose Drug from Matrix Tablets Composed Blends Swellable Erodible Polymers: Implications for Controlled Complete ReleaseAiman A. Obaidat