BACKGROUND It is estimated that over 190 million bisphosphonates have been prescribed worldwide. But this drug can produce adverse effects, of which osteonecrosis of the jaw and severe hypocalcemia are the most serious. It is evident that bisphosphonate administration affects multiple and diverse biochemical mediators related to bone metabolism. MATERIAL AND METHODS This review of literature ...

OBJECTIVE To assess the awareness and knowledge of physicians and dentists regarding bisphosphonates related osteonecrosis of the jaw (BRONJ). METHODS A cross-sectional descriptive study was carried out in the Department of Dentistry, Riyadh Military Hospital, Kingdom of Saudi Arabia from June to September 2010. Data were collected through a self-administered questionnaire distributed among a...

The aim of this longitudinal study is to present data from 76 female patients treated with bisphosphonates (BPs) for postmenopausal osteoporosis and referred to the Unit of Oral Diagnosis and Day Surgery of the University of Milano for diagnosis and treatment. All patients received a thorough oral examination. The diagnosis of osteonecrosis of the jaw bone (ONJ) was made from radiographic and c...

Bisphosphonate is the collective name for compounds in which the backbone of pyrophosphoric acid, a P-O-P structure, is converted to chemically stable P-C-P, and this structure shows the affinity of bisphosphonate for bone hydroxyapatite in the body (Fleisch et al. 2002). Administered bisphosphonate preparations (BPs) transfer to and deposit in bone, exhibiting a bone resorption-inhibitory effe...