PURPOSE The purpose of this study was to evaluate the effects of intraocular pressure on the permeability of human and rabbit sclera to water, dexamethasone, and carboxyfluorescein. METHODS Scleral sections excised from moist-chamber-stored human globes or eyes obtained from euthanatized New Zealand White rabbits were mounted in a perfusion chamber that can create a transscleral pressure that...

Changes in both intraocular pressure and total outflow facility were determined after short- and long-term infusion and topical application of prostaglandin E1 and E2. The intraocular pressure with both routes of administration increased within 15 minutes by 10 to 15 mm. Hg; long-term infusion caused the intraocular pressure to be elevated for a longer time, although a fall in intraocualr press...

An equation has been derived under simplified assumptions showing how the steady-state value of intraocular pressure depends on rate of secretion of aqueous, episcleral venous pressure, outflow facility at the chamber angle, colloid-osmotic pressure of the blood, systemic arterial blood pressure, pressure distribution over the vascular tree of the eye, and filtration properties of the vasculatu...

The aim of this study was to investigate the association between postprandial glucose and intraocular pressure in a relatively healthy population. We examined 1,439 adults getting a health check-up in a health promotion center at Tri-Service General Hospital (TSGH) in Taiwan between 2012 and 2013. All participants underwent examinations to measure metabolic variables and intraocular pressure. M...

In an attempt to determine the presence or absence of correlation between the intraocular pressure-increasing and pupil-dilating effects of corticosteroids, the effect of topically applied dexamethasone and various autonomic agents has been studied in 12 hospitalised, healthy, young adult volunteers. Dexamethasone caused an average increase of intraocular pressure of 8-8 mmHg and of pupillary d...

PURPOSE Intraocular pressure (IOP) spikes that occur during cyclocryotherapy for advanced glaucoma may further injure the already damaged glaucomatous optic nerve and be responsible for visual impairment that may occur after this treatment. The authors investigated the mechanism of pressure rise to see whether it can be avoided and thus prevent further optic nerve injury. The authors postulated...

Axonal transport in primate optic nerve axons was studied by autoradiography, scintillation counting, and electron microscopy under conditions of short-term intraocular pressure elevation. With elevation of intraocular pressure to 30 mm. Hg below mean arterial blood pressure, blockage of transport was detected within 2 hours by autoradiography and within 1 hour by electron microscopy. The earli...

The relationship of the ophthalmic pulse amplitude to the intraocular pressure has been described in rabbits and dogs. The effect of a suction cup on the intraocular pressure has been investigated in rabbit eyes and human eyes. Sample pulse tracings have been obtained using a suction cup on rabbits and man. Two estimates were made of the volume changes associated with the ophthalmic pulse xoave...

Purpose. The assessment of the incidence of ocular hypertension over a period of 1 year in patients treated with multiple intravitreal injections of anti-VEGF agents for neovascular AMD. Methods. The study comprised 58 eyes diagnosed with neovascular age-related macular degeneration and receiving PRN intravitreal treatment with anti-VEGF agents (bevacizumab or aflibercept). The follow-up period...

PURPOSE The dynamic contour tonometer is a nonapplanation contact tonometer designed to be largely independent of the structural properties of the cornea. Theoretically, it may measure intraocular pressure most accurately in abnormally thinner corneas. This study compares intraocular pressure measurements by dynamic contour tonometry with Goldman applanation tonometry in eyes with normal cornea...