α-catenin associates the cadherin-catenin complex with the actin cytoskeleton. α-catenin binds to β-catenin, which links it to the cadherin cytoplasmic tail, and F-actin, but also to a multitude of actin-associated proteins. These interactions suggest a highly complex cadherin-actin interface. Moreover, mammalian αE-catenin has been implicated in a cadherin-independent cytoplasmic function in A...

This study investigated the effect of the Rho kinase inhibitor Y-27632 and fasudil on the development of human mesangial cell (HMC) inflammation and fibrosis induced by high glucose and to clarify the contribution of the Rho/ROCK signaling pathway in the pathogenesis of diabetic kidney disease (DKD). High glucose (30 mmol/l) induced the Rho/ROCK signaling pathway. Western blotting was used to d...

Understanding the mechanisms that drive acid-base regulation in organisms is important, especially for organisms in aquatic habitats that experience rapidly fluctuating pH conditions. Previous studies have shown that carbonic anhydrases (CAs), a family of zinc metalloenzymes, are responsible for acid-base regulation in many organisms. Through the use of phylogenetic tools, this present study at...

XTE J1908+094 is an X-ray transient that went into outburst in February 2002. After two months it reached a 2-250 keV peak flux of 1 to 2 × 10 erg cms. Circumstantial evidence points to an accreting galactic black hole as the origin of the the X-radiation: pulsations nor thermonuclear flashes were detected that would identify a neutron star and the spectrum was unusually hard for a neutron star...

Background and Objectives: Pregnancy is one of the important periods of life in women and it is essential to have mental health. Spiritual constructs and life skills play an important role in explaining the psychological empowerment of people. The aim of the current study was to investigate the role of spiritual health and emotional regulation in mental health of nulliparous women. Methods: In...

objective: infertility is considered as an intense and prolonged stressful experience. despite of high prevalence of infertility and its emotional burden for couples and especially for women, materials and methods: the knowledge regarding psychological factors influencing adjustment to it is limited. the aim of the present study was to investigate the mediational role of cognitive emotion regul...