Epilepsy is a neurological disorder that disrupts the normal transmission of electrical signals in the brain and is characterised by abnormal electrical neuronal activity resulting clinically in unprovoked recurring seizures. Partial-onset seizures are those that involve only a portion of the brain at seizure onset. The prevalence of epilepsy varies between 4 and 8 cases per 1,000 individuals i...

BACKGROUND Malignant migrating partial seizures in infancy is a devastating pharmacoresistent epileptic encephalopathy of unknown etiology characterized by onset in the first 6 months of life, continuous migrating focal seizures with corresponding multifocal electroencephalographic discharges, developmental deterioration, and early mortality. Recent widespread interest in the nonpsychoactive co...

Obstructive sleep apnea (OSA) is common in patients with refractory epilepsy and may exacerbate seizures. In epileptic patients with OSA, seizures occur more frequently during sleep. Seizure frequency may be reduced by treating OSA and increase if the treatment is interrupted or neglected. It is not clear how OSA provokes seizures. Multiple seizureprovoking factors including cerebral hypoxemia,...

BACKGROUND Isodicentric 15 syndrome (IDIC-15) is due to partial duplications of chromosome 15 that may includes the q11-13 region that includes genes encoding the α5 (GABRA5) and β3 - γ3 (GABRB3) receptor subunits. The disease causes intellectual and physical developmental delay, seizures, intellectual disability and behavioral disorders that may be related to abnormal GABA receptor function an...

Case presentation: H.M.B.R., female, 5 years, mother with gestational diabetes. Birth weight of 4240 g, full term, APGAR 9/9, neonatal hypoglycemia as intercurrence. At the age 11 months and 14 days had her first epileptic seizure, being hospitalized treated phenobarbital, no effective response. Family history epilepsy. 2 years 8 months, was reassessed for worsening refractory epilepsy associat...