A 15-year-old white girl presented with headaches and night sweats of 2 weeks’ duration. Her platelet count was 50 10/ L (50 10/L) [reference interval, 140–440 10/ L (140–440 10/L)]. Upon referral to hematology/oncology, the patient had a leukocyte count of 21 10/ L (21 10/L) [reference interval, 3.8–9.8 10/ L (3.8–9.8 10/L)] with 46% lymphoblasts. The patient was diagnosed with pre-B acute lym...

We investigated the single- and multiple dose pharmacokinetics of a new controlled-release formulation (Orfil retard enteric coated tablet) of valproic acid in comparison with those of the plain tablet as a reference. Twelve healthy volunteers were given each formulation of 300 mg in the single-dose study. In the steady-state multiple-dose study, twelve epileptic patients received 1200 mg/day o...

Maternal thyroid hormone levels during pregnancy play a crucial role in the development of neonates and children.1 Any gestational period thyroid hormone disorder may lead to obstetrical complications along with effects on the fetus.2 Fetal growth is also affected by maternal thyroid levels.3 Various physiological changes, alterations of thyroxine-binding globulins, human chorionic gonadotropin...

With the combination of the model reference adaptive control and iterative learning control, a model reference adaptive iterative learning control algorithm was proposed for a class of first order linear time-varying systems which are BIBO stable and repeatable in a finite time interval . By means of Lyapunov technique , an iterative learning control law with adaptive update law for time-varyin...

The practice of pediatric laboratory medicine involves unique challenges related to development, nutrition, growth and diseases during different periods of infancy, childhood and adolescence. Pediatric patients require a unique medical approach, as significant differences exist in disease frequencies, specimen collection, test performance and test interpretation. In the last two decades, clinic...

The practice of pediatric laboratory medicine involves unique challenges related to development, nutrition, growth and diseases during different periods of infancy, childhood and adolescence. Pediatric patients require a unique medical approach, as significant differences exist in disease frequencies, specimen collection, test performance and test interpretation. In the last two decades, clinic...