The bioavailability of two dipyridamol tablet formulations of (Dipyridamole from Tolidaru and Persantin from Boehringer) was compared in 14 healthy male volunteers who received a single dose of 25 mg of the test (T) and the reference (R) products in a randomized balanced 2-way crossover design. Plasma samples were obtained over a 16 h interval and dipyridamole concentrations determined by HPLC ...

Cefixime is a significant member of orally active third generation cephalosporin and has excellent activity against many pathogens. The virtual bioavailability of a newly industrial dispersible tablet as compared with a recognized identified formulation. An open-label, single-dose, randomized, 2-way crossover study was conducted in fasted healthy Iranian male volunteers. Eligible participa...

The goal of this study is to assess whether a growth curve model approach will lead to a more precise detection of Turner sydnrome (TS) than conventional referral criteria for growth monitoring. The Jenss-Bayley growth curve model was used to describe the process of growth over time. A new screening rule is defined on the parameters of this growth curve model, parental height and gestational ag...

a rapid, sensitive and reproducible hplc method using amperometric detector was developed and validated for the analysis of clarithromycin in human plasma. the separation was achieved on a monolithic silica column (mz- c8 125×4.0 mm) using acetonitrile- methanol-potassium dihydrogen phosphate buffer (40:6:54,v/v), with ph of 7.5, as the mobile phase at a flow rate of 1.5 ml/min. the assay enabl...

in this study, a new reaction system for quantitative determination of ascorbic acid was introduced. the developed method is based on inhibitory effect of ascorbic acid on the orange g-bromate system. the change in absorbance was followed spectrophotometrically at 478 nm. the dependence of sensitivity on the reaction variables including reagents concentration, temperature and time was investiga...

iran’s vast common natural gas resources and the necessity to extract and export it as liquefied natural gas (lng) to distances more than 3000km opens a lucrative field for researchers to optimize lng cycles. in this article heat integration in cryogenic cycles by determining interacycle partition temperature and optimizing refrigeration features like subcooler, presaturator, aftercooler, reboi...

We present a nonarchimedian method to construct hyperelliptic CM-curves of genus 2 over finite prime fields. Throughout the document we use the following conventions (this is only for the reference and use of the authors): d degree of the base field of the curve, i.e. C/F 2 d s number of isomorphism classes, in elliptic curve case s = h K n degree of an irreducible component of class invariants...

The continuous casting tundish is a very important metallurgical reactor in production. flow characteristics of tundishes are usually evaluated by residence time distribution (RTD) curves. At present, the analysis model RTD curves still has limitations. In this study, we reviewed curve models single and multi-flow tundish. We compared mixing modified combination for same time, multi-strand were...

A 3D mathematical model of orthodontic archwire with rectangular curve is established. Simplified 3D solid model of orthodontic archwire bending robot, which is consistent of bending die, support structure and archwire are established by Creo software, then the simplified model of bending die is put into ANSYS Workbench. Material parameters the contact condition and boundary conditions are set ...