نتایج جستجو برای: reelin gene

تعداد نتایج: 1141824  

Journal: :Neuron 2013
Manjot Bal Jeremy Leitz Austin L. Reese Denise M.O. Ramirez Murat Durakoglugil Joachim Herz Lisa M. Monteggia Ege T. Kavalali

Reelin is a glycoprotein that is critical for proper layering of neocortex during development as well as dynamic regulation of glutamatergic postsynaptic signaling in mature synapses. Here, we show that Reelin also acts presynaptically, resulting in robust rapid enhancement of spontaneous neurotransmitter release without affecting properties of evoked neurotransmission. This effect of Reelin re...

Journal: :The EMBO journal 2008
Sophia M Blake Vera Strasser Nuno Andrade Sarah Duit Reinhold Hofbauer Wolfgang J Schneider Johannes Nimpf

Apolipoprotein E receptor 2 (ApoER2), very low-density lipoprotein receptor (VLDLR), and Dab1 are the main components of the Reelin signalling cascade. Reelin is the sole ligand defined so far in signalling through this pathway. Postnatal migration of neuronal precursors from the subventricular zone (SVZ) to the olfactory bulb (OB), however, depends on ApoER2 and Dab1, but functions independent...

Journal: :American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2004
K L Raiford Y Shao I C Allen E R Martin M M Menold H H Wright R K Abramson G Worley G R DeLong J M Vance M L Cuccaro J R Gilbert M A Pericak-Vance

Autism is a neurodevelopmental disorder characterized by stereotypic and repetitive behavior and interests, together with social and communicative deficiencies. The results of several genomic screens suggest the presence of an autism susceptibility locus on chromosome 19p13.2-q13.4. The apolipoprotein E (APOE) gene on chromosome 19 encodes for a protein, apoE, whose different isoforms (E2, E3, ...

Journal: :Archives of general psychiatry 2000
A Guidotti J Auta J M Davis V Di-Giorgi-Gerevini Y Dwivedi D R Grayson F Impagnatiello G Pandey C Pesold R Sharma D Uzunov E Costa

BACKGROUND Reelin (RELN) is a glycoprotein secreted preferentially by cortical gamma-aminobutyric acid-ergic (GABAergic) interneurons (layers I and II) that binds to integrin receptors located on dendritic spines of pyramidal neurons or on GABAergic interneurons of layers III through V expressing the disabled-1 gene product (DAB1), a cytosolic adaptor protein that mediates RELN action. To repli...

2016
Hector Carceller Laura Rovira-Esteban Juan Nacher Eero Castrén Ramon Guirado

Reelin, a glycoprotein expressed by Cajal-Retzius neurons throughout the marginal layer of developing neocortex, has been extensively shown to play an important role during brain development, guiding neuronal migration and detachment from radial glia. During the adult life, however, many studies have associated Reelin expression to enhanced neuronal plasticity. Although its mechanism of action ...

Journal: :Neuroscience 2006
S A Villeda A L Akopians A H Babayan A I Basbaum P E Phelps

Mutations in reeler, the gene coding for the Reelin protein, result in pronounced motor deficits associated with positioning errors (i.e. ectopic locations) in the cerebral and cerebellar cortices. In this study we provide the first evidence that the reeler mutant also has profound sensory defects. We focused on the dorsal horn of the spinal cord, which receives inputs from small diameter prima...

2011
Galit Ovadia Sagiv Shifman

Reelin plays an important role in the development and function of the brain and has been linked to different neuropsychiatric diseases. To further clarify the connection between reelin and psychiatric disorders, we studied the factors that influence the expression of reelin gene (RELN) and its different isoforms. We examined the total expression of RELN, allelic expression, and two alternative ...

2017
Liang Wang Jonathan A. Cooper

The Reelin-Dab1 signaling pathway regulates development of the mammalian brain, including neuron migrations in various brain regions, as well as learning and memory in adults. Extracellular Reelin binds to cell surface receptors and activates phosphorylation of the intracellular Dab1 protein. Dab1 is required for most effects of Reelin, but Dab1-independent pathways may contribute. Here we deve...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2004
Yves Jossin Nina Ignatova Thomas Hiesberger Joachim Herz Catherine Lambert de Rouvroit André M Goffinet

Reelin is a large extracellular protein that controls cortical development. It binds to lipoprotein receptors very-low-density lipoprotein receptor and apolipoprotein-E receptor type 2, thereby inducing phosphorylation of the adapter Dab1. In vivo, Reelin is cleaved into three fragments, but their respective function is unknown. Here we show the following: (1) the central fragment is necessary ...

Journal: :Cerebral cortex 2011
Alexis M Stranahan Rebecca P Haberman Michela Gallagher

Brain regions and neural circuits differ in their vulnerability to changes that occur during aging and in age-related neurodegenerative diseases. Among the areas that comprise the medial temporal lobe memory system, the layer II neurons of the entorhinal cortex, which form the perforant path input to the hippocampal formation, exhibit early alterations over the course of aging Reelin, a glycopr...

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