background coronary artery disease (cad) is the most common cause of death worldwide. mef2a directly regulates target genes in the process of muscle development. this gene product is a transcription factor. mef2a protein in homodimer or heterodimer forms binds to a/t-rich cis elements with conserved sequence in promoter, regulator, and enhancer of many genes, which are determining in evolution ...

several epidemiological studies have reported that passive smoking (ps) is a public health hazard and perhaps increases the risk of heart disease. this study evaluated the relationship between female coronary heart disease and ps among married women who described themselves as non-smokers in an area of south-east iran. using household exposure to tobacco smoke as an estimate of ps, a hospitalba...

AIMS Recent genetic studies identified the rs1333049 variant on chromosome 9p21 as a major susceptibility locus for coronary artery disease and myocardial infarction (MI). Here, we evaluated whether this variant also contributes to recurrent MI or cardiac death following an acute coronary syndrome (ACS). METHODS AND RESULTS A total of 3247 patients with ACS enrolled in the Global Registry of ...

Clinical trials have clearly shown that low density lipoprotein (LDL)-cholesterol lowering reduces coronary heart disease morbidity and mortality in patients with established coronary heart disease and LDL-cholesterol above 3·4 mmol . l . However, about 40% of coronary heart disease patients do not have elevated levels of LDL-cholesterol and many of them have low levels of high density lipoprot...

Introduction: Coronary artery disease is the most common type of cardiovascular disease. Despite the increasing number of patients with coronary artery disease, the lived experiences of these patients have remained unknown. The purpose of the study was to understand the lived experiences of elderly patients with coronary artery disease. Methods: This qualitative research was conducted usin...

A 76-year-old patient was admitted to hospital due to recurrent chest pain. Angiography revealed multivessel coronary artery disease with significant stenosis in medial and distal parts of the left main coronary artery (LMCA). Two drug-eluting stents (DES) were implanted from the medial part of the LMCA to the proximal part of the left anterior descending (LAD) artery. An excellent angiographic...

Acute myocardial infarction (MI) patients remain at high risk for recurrent events. Cholesterol efflux, mediated by apolipoprotein A-I, removes excess cholesterol from atherosclerotic plaque and transports it to the liver excretion. Impaired efflux is associated with higher cardiovascular (CV) event rates among both stable coronary artery disease recent MI. CSL112, a novel intravenous formulati...

BACKGROUND Kawasaki disease (KD) without affection of the coronary artery system is rare. Optic nerve pathology together with KD has not been described earlier. CASE PRESENTATION We present one case of KD in a 12-year-old girl predominantly with prolonged cholestasis, and a second case of multiple recurrent KD in a 9-year-old boy with hepatomegaly and ischemic optic nerve neuropathy. The coro...

Coronary artery spasm (CAS), an intense vasoconstriction of coronary arteries that causes total or subtotal vessel occlusion, plays an important role in myocardial ischemic syndromes including stable and unstable angina, acute myocardial infarction, and sudden cardiac death. Coronary angiography and provocative testing usually is required to establish a definitive diagnosis. While the mechanism...