INTRODUCTION The purpose of this article is to describe the successful recruitment methods of a study focused on a pilot intervention for rural women who were experiencing abuse and who also were at risk for sexually transmitted infections. Initial recruitment into the study was the primary challenge, and strategies to overcome recruitment difficulties are discussed. METHODS Eighty-seven wome...

A controversy exists about the effects of violent video game play, with some studies showing “positive” effects on spatial attention, others showing “negative” effects on aggression, and others suggesting that there are no important effects. The present study examined neural recruitment during violent videogame play among 13 late adolescent gamers, half of whom habitually played violent games a...

Activating receptors such as NKG2D and Ly49D mediate a multitude of effector functions including cytotoxicity and cytokine generation in NK cells. However, specific signaling events that are responsible for the divergence of distinct effector functions have yet to be determined. In this study, we show that lack of caspase recruitment domain-containing protein Bcl10 significantly affected recept...

Apaf-1 and cytochrome c coassemble in the presence of dATP to form the apoptosome. We have determined a structure of the apoptosome at 12.8 A resolution by using electron cryomicroscopy and single-particle methods. We then docked appropriate crystal structures into the map to create an accurate domain model. Thus, we found that seven caspase recruitment domains (CARDs) form a central ring withi...

Abstract Organizations’ hiring processes are increasingly shaped by various digital tools and e-recruitment systems. However, there is little understanding of the recruiters’ needs for expectations towards new This paper investigates recruitment chatbots as an emergent form e-recruitment, offering a low-threshold channel recruiter-applicant interaction. The rapid spread casual nature their user...

Lung recruitment maneuvers are being used in the management of acute lung injury and acute respiratory distress syndrome, but recruitment maneuvers are controversial. The proponents argue that when properly applied to appropriately selected patients, they are effective and can be safely applied. The expectation is that the recruitment maneuver will change the course of ARDS and improve outcomes...

Methods Randomised clinical trials of any health care intervention, conducted between 2006 and 2012 and closed to recruitment, were identified. Recruitment performance was assessed by comparing achieved to planned recruitment. Putative factors affecting recruitment will be tested for association with successful recruitment, defined initially as recruitment to 100% of target in the planned time ...

Thoughts arise spontaneously in our minds with remarkable frequency, but tracking the brain systems associated with the early inception of a thought has proved challenging. Here we addressed this issue by taking advantage of the heightened introspective ability of experienced mindfulness practitioners to observe the onset of their spontaneously arising thoughts. We found subtle differences in t...

Apaf-1 facilitates the proteolytic activation of procaspase-9 and maintains the hyperactive state of the processed caspase-9. The underlying molecular mechanisms for these activities remain poorly characterized. Here we report that the isolated Apaf-1 caspase recruitment domain (CARD) forms a large hetero-oligomer with the active caspase-9. The catalytic activity of caspase-9 is significantly e...