نتایج جستجو برای: recombinant plasminogen activator

تعداد نتایج: 159071  

2017
Slaven Pikija Laszlo K Sztriha J Sebastian Mutzenbach Stefan M Golaszewski Johann Sellner

BACKGROUND AND PURPOSE Current guidelines do not recommend the use of intravenous recombinant tissue plasminogen activator in patients with acute ischemic stroke who receive direct oral anticoagulants. While the humanized monoclonal antibody idarucizumab can quickly reverse the anticoagulant effects of the thrombin inhibitor dabigatran, safety data for subsequent tissue plasminogen activator tr...

Journal: :Stroke 2010
Keun-Sik Hong Jeffrey L Saver

BACKGROUND AND PURPOSE Disability-adjusted life year (DALY) metric reflects years of healthy life lost because of living with disability and years of life lost because of premature mortality. Widely used in epidemiological analyses, DALY has not been applied to acute stroke trials. METHODS From previous studies, we derived, for each modified Rankin Scale level, disability weights, disability-...

Journal: :Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics 1990

Journal: :Stroke 2010
Pooja Khatri Dawn O Kleindorfer Sharon D Yeatts Jeffrey L Saver Steven R Levine Patrick D Lyden Charles J Moomaw Yuko Y Palesch Edward C Jauch Joseph P Broderick

BACKGROUND AND PURPOSE The pivotal National Institute of Neurological Disorders and Stroke recombinant tissue plasminogen activator trials excluded patients with ischemic stroke with specific minor presentations or rapidly improving symptoms. The recombinant tissue plasminogen activator product label notes that its use for minor neurological deficit or rapidly improving stroke symptoms has not ...

Journal: :Stroke 2013
Masahiko Ichijo Kazunori Miki Satoru Ishibashi Makoto Tomita Tomoyuki Kamata Hiroto Fujigasaki Hidehiro Mizusawa

BACKGROUND AND PURPOSE Prominent posterior cerebral artery (PCA) laterality upon 3-dimensional time-of-flight magnetic resonance angiography is often encountered in patients with middle cerebral artery occlusion. We hypothesized that this sign is correlated with improved functional outcome in patients with middle cerebral artery occlusion treated with intravenous recombinant tissue plasminogen ...

Journal: :Stroke 2008
Jürgen Eggers Inke R König Björn Koch Götz Händler Günter Seidel

BACKGROUND AND PURPOSE Sonothrombolysis is a new treatment approach in acute ischemic stroke. The results of a monocenter, randomized clinical study are presented. METHODS Subjects with acute middle cerebral artery main stem occlusion were randomized into a target group receiving 1-hour transcranial continuous insonation using a 1.8-MHz Doppler ultrasound (US) probe or a control group. All un...

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