background: hypospadias is one of the most common congenital abnormalities in the male which is characterized by altered development of urethra, foreskin and ventral surface of the penis. androgen receptor gene plays a critical role in the development of the male genital system by mediating the androgens effects. objective: in present study, we looked for new variations in androgen receptor pro...

the aim of this study was to use site directed mutagenesis technique to construct a vector in which serine363 and serine375 residues of the cooh-terminal portion of the μ-opioid receptor (mor) were substituted by alanine. these constructs are essential in studying g-protein coupled receptor kinase-mediated mor desensiti-zation. the nested pcr carried out for conversion of serine363 and serine37...

©2017 Turkish League Against Rheumatism. All rights reserved. ABSTRACT Objectives: This study aims to observe both transient receptor potential ankyrin 1 (TRPA1) and transient receptor potential vanilloid 4 (TRPV4) expressions in synovial tissues of rats with mechanical hyperalgesia induced by experimental knee osteoarthritis (KOA). Patients and methods: Forty-five four-month-old Sprague Dawley...

Mathematical modeling of bacterial chemotaxis systems has been influential and insightful in helping to understand experimental observations. We provide here a comprehensive overview of the range of mathematical approaches used for modeling, within a single bacterium, chemotactic processes caused by changes to external gradients in its environment. Specific areas of the bacterial system which h...