Toll-interacting protein (Tollip) is a critical regulator of TOLL- like receptor (TLR)-signaling pathway. It predominantly associated with TLR2 and TLR4 during acute inflammatory conditions inhibits the TLR-mediated nuclear factor-kappa activation by suppressing autophosphorylation interleukin-1 receptor-associated kinase its activity. This article describes Tollip Labeo rohita (LrTollip), high...

Abbreviations: PI3K-Akt: Phosphatidylinositol-3-Kinase and Protein Kinase B; Rac1: Ras-Related C3 Botulinum Toxin Substrate 1; LN332: Laminin 332; EGF: Epidermal Growth Factor; EGF-R: Epidermal Growth Factor Receptor; IGF1&IGF-II: Insulin-Like Growth Factor 1&2; Gtpase: Guanosine 5’-Triphosphate Hydrolase Enzyme; IRS-1, IRS-2: Insulin Receptor Substrate 1&2; ERK: Extracellular Receptor Kinase; ...

Abbreviations: PI3K-Akt: Phosphatidylinositol-3-Kinase and Protein Kinase B; Rac1: Ras-Related C3 Botulinum Toxin Substrate 1; LN332: Laminin 332; EGF: Epidermal Growth Factor; EGF-R: Epidermal Growth Factor Receptor; IGF1&IGF-II: Insulin-Like Growth Factor 1&2; Gtpase: Guanosine 5’-Triphosphate Hydrolase Enzyme; IRS-1, IRS-2: Insulin Receptor Substrate 1&2; ERK: Extracellular Receptor Kinase; ...

Intercellular signaling plays an important role in controlling cellular behavior in apical meristems and developing organs in plants. One prominent example in Arabidopsis is the regulation of floral organ shape, ovule integument morphogenesis, the cell division plane, and root hair patterning by the leucine-rich repeat receptor-like kinase STRUBBELIG (SUB). Interestingly, kinase activity of SUB...

Recent data on the plasma membrane (PM)-located LRR-RLKs (for Leu-rich repeat receptor-like kinases) BRI1 (for brassinosteroid insensitive 1) and the coreceptors BAK1 (for BRI1-associated kinase 1) and SERK1 (for somatic embryogenesis receptor-like kinase 1) that participate in the perception of brassinosteroids (BRs) suggest that they are organized into heterooligomeric protein complexes. Othe...

Insulin-like growth factor I (IGF-I) and insulin receptors are structurally similar with ligand-stimulated tyrosine kinase activity in their cytoplasmic domains. The function of the insulin receptor tyrosine kinase in signal transduction has been studied extensively in contrast to the IGF-I receptor tyrosine kinase. In the present study we have analyzed the regulatory function of the IGF-I rece...

A cDNA encoding a chitinase-related receptor-like kinase, designated CHRK1, was isolated from tobacco (Nicotiana tabacum). The C-terminal kinase domain (KD) of CHRK1 contained all of the conserved amino acids of serine/threonine protein kinases. The putative extracellular domain was closely related to the class V chitinase of tobacco and to microbial chitinases. CHRK1 mRNA accumulation was stro...

Arabidopsis sol2 mutants showed CLV3 peptide resistance. Twenty-six synthetic CLE peptides were examined in the clv1, clv2 and sol2 mutants. sol2 showed different levels of resistance to the various peptides, and the spectrum of peptide resistance was quite similar to that of clv2. SOL2 encoded a receptor-like kinase protein which is identical to CORYNE (CRN). GeneChip analysis revealed that th...

Protein kinase C (PKC) is a family of kinases that are implicated in a plethora of diseases, including cancer and cardiovascular disease. PKC isoforms can have different, and sometimes opposing, effects in these disease states. Toll-like receptors (TLRs) are a family of pattern recognition receptors that bind pathogens and stimulate the secretion of cytokines. It has long been known that PKC in...

AMP: Deaminase Adenosine Monophosphate Deaminase; ATP 7B: Membrane-Bound Copper-Binding Adenosine Triphosphatase; cGMP: Guanosine 3’, 5’ Cyclic Monophosphate; DC: Dendritic Cells; DNA: Deoxyribonucleic Acid; dTMP: Deoxythymidine 5’ Mono-Phosphate; HL-60: Human promyelocytic Leukemia cell line; HUT-78: Human malignant lymphoblastoid cell line of Th0 phenotype; ICAM-1: Soluble Intercellar Adhesio...