This study aimed to attain a comparison in pharmacokinetic parameters of ondansetron after transdermal (as invasomes gel) and oral solution) routes. Ondansetron is 5 ? hydroxytryptamine receptor antagonist used for chemotherapy radiotherapy induced nausea emesis. The was performed using Wistar albino rats weighing 200 ±20 g divided into two groups (6 each). A dose 0.28 mg ondansetron, eq...

The first line treatments for acute gouty arthritis are nonsteroidal anti-inflammatory drugs (NSAID), corticosteroids, and colchicine. However, these agents ineffective or contraindicated in a proportion of patients. Interleukin (IL)-1 is key mediator the pathogenesis arthritis. Recently, three IL-1-targeted have been developed, including anakinra, IL-1 receptor antagonist. authors present two ...

Introduction: The Bed nucleus stria terminalis (BST) is a part of the limbic system. It was recently shown that chemical stimulation of the BST by L-glutamate elicited cardiovascular depressive responses. In the present study, we have investigated the possible cardiovascular role of the GABAergic receptors in BST by microinjection of its agonist and antagonists. Methods: Experiments were p...

This study was designed to investigate the role of GABAB receptor agents on imipramine-induced antinociception in ligated and non-ligated mice using hot-plate test. The data showed that different doses of morphine (3, 6, and 9 mg/kg) induced a dose-dependent antinociception in ligated and non-ligated mice. However, the opioid response was decreased in ligated animals. Intracerebroventricular (i...

adenosine receptor family especially a1 type is expressed in breast cancer cells in which p53 and caspase genes are wild-type. the aim of this study was to investigate the correlation between a1 receptor and either cell apoptosis or proliferation and also to recognize the relationship between this receptor and p53 and the expression of caspases 3, 8 and 9 in mcf-7 cell line. mcf-7 cells were tr...

We have already reported that 5-hydroxytryptamine3 (5-HT3) receptor antagonists failed to modify 5-HT-accelerated colonic transit in conscious rats, but the 5-HT3 and 5-HT4 receptor dual antagonist FK1052 prevented the enhancement. In this study, the inhibitory effect on the stimulated colonic transit was not also observed with 5-HT4 receptor antagonists (SDZ205-557 and SB204070) in freely movi...

Background: The ventral tegmental area (VTA) is well known for its role in cardiovascular control. It is demonstrated that about 20-30% of the VTA neurons are GABAergic though their role in cardiovascular control is not yet understood. This study is carried out to find the effects of GABA A and GABA B receptors on cardiovascular response of the VTA. Methods: Experiments were performed on uretha...

Introduction: Stimulation or inactivation of the lateral hypothalamus (LH) produces antinociception. Studies showed a role for the ventral tegmental area (VTA) in the antinociception induced by LH chemical stimulation through the orexinergic receptors. In this study, we assessed the role of intra-VTA dopamine D1 and D2 receptors in antinociceptive effects of cholinergic agonist, carbachol, m...