This work critically discusses the direct and indirect effects of natural polyamines their catabolites such as reactive oxygen species ?-aminobutyric acid on activity key plant ion-transporting proteins plasma membrane H + Ca 2+ ATPases K -selective cation channels in tonoplast, context involvement stress responses. Docking analysis predicts a distinct binding for putrescine longer within pore ...

In recent years, most companies have resorted to multi-site or supply-chain organization in order to improve their competitiveness and adapt to existing real conditions. In this article, a model for adaptive scheduling in multi-site companies is proposed. To do this, a multi-agent approach is adopted in which intelligent agents have reactive learning capabilities based on reinforcement learning...

The common sequence of amino acids about a reactive serine in four proteolytic enzymes derived from four different strains of B. subtilis has been reported.1' 2 The sequence is -threonyl-seryl-methionyl-alanine-. This sequence is significantly different from that reported for a variety of proteolytic enzymes derived from mammalian sources which also contain one uniquely reactive serine, namely,...

According to recent estimates, cancer continues to remain the second leading cause of death and is becoming the leading one in old age. Failure and high systemic toxicity of conventional cancer therapies have accelerated the identification and development of innovative preventive as well as therapeutic strategies to contrast cancer-associated morbidity and mortality. In recent years, increasing...

Multiple field studies have suggested chemistry within a forest canopy is poorly understood due to inadequate detection and quantification of reactive biogenic emissions, such as terpenes. To measure emission rates of terpenes at Blodgett Forest, a coniferous forest in the Sierra Nevada mountains of California, we placed enclosures over branches of the dominant species at the site – Ponderosa p...

Critical elements from studies that have led to our current understanding of the factors that cause the observed primary deuterium isotope effect, (kH/kD)obs, of most enzymatically mediated reactions to be much smaller than the "true" or intrinsic primary deuterium isotope effect, kH/kD, for the reaction are presented. This new understanding has provided a unique and powerful tool for probing t...

Researchers in the post-genome era are confronted with the daunting task of assigning structure and function to tens of thousands of encoded proteins. To realize this goal, new technologies are emerging for the analysis of protein function on a global scale, such as activity-based protein profiling (ABPP), which aims to develop active site-directed chemical probes for enzyme analysis in whole p...

The three-dimensional structure of the Bowman-Birk type proteinase inhibitor (PI-II) has been determined by x-ray crystallography and refined at 2.5-A resolution. This protein is a specific inhibitor of trypsin. Two reactive site loops, one at each end of the PI-II molecule, are structurally similar to each other and to reactive-site loops of pancreatic secretory trypsin inhibitor (Bolognesi, M...