UNLABELLED During lymphocyte migration, engagement of VCAM-1 stimulates the generation of endothelial cell-derived reactive oxygen species (ROS) and activation of matrix metalloproteinases, facilitating endothelial retraction. Because bilirubin is a potent antioxidant, we examined the hypothesis that this bile pigment inhibits VCAM-1-dependent cellular events. The migration of isolated murine s...

The aim of the present study was to measure adenosine triphosphate (ATP) levels in CD4+ T cells as a marker of T-cell activity following surgery for colorectal cancer using the ImmuKnow assay kit. A total of 16 consecutive patients who underwent surgical resection for colorectal cancer between August and December, 2012 were enrolled in this study, of whom 7 underwent laparoscopic resection and ...

Following an ischemic stroke, T lymphocytes become activated, infiltrate the brain, and appear to release cytokines and reactive oxygen species to contribute to early inflammation and brain injury. However, some subsets of T lymphocytes may be beneficial even in the early stages after a stroke, and recent evidence suggests that T lymphocytes can also contribute to the repair and regeneration of...

Background: Sepsis is a condition in systemic infection associated with organdysfunction. Interleukin-17 pro-inflammatory cytokine produced by Th-17 cells. C-reactive protein and neutrophil-lymphocyte ratio (NLR) have been widely used asmarkers of inflammation. The relationship between IL-17 as proinflammatorycytokine CRP NLR has not reported.Objective: This study aims to prove the correlation ...

Background Longitudinal associations between leukocyte subtype counts and LDL cholesterol have not been reported. Methods and Results This is a retrospective observational study in a health screening population. Spearman's correlation coefficients were calculated between leukocyte subtype counts and LDL cholesterol levels at baseline and after four years. Using Cox regression models, hazard r...

STUDY DESIGN Case control study. PURPOSE To identify the most significant laboratory marker for early detection of surgical site infection (SSI) using multiple logistic regression analysis. OVERVIEW OF LITERATURE SSI is a serious complication of spinal instrumentation surgery. Early diagnosis and treatment are crucial. METHODS We retrospectively reviewed the laboratory data of patients wh...

Coronavirus disease 2019 (COVID-19) was announced in early December 2019. By genome sequencing, the virus recognised. From Wuhan City, spread globally. The pandemic situation declared by World Health Organization.The first case of COVID-19 Indiawas reported Kerala on January 27, 2020.The clinical features varied with severity. Most patients have non-severe manifestations and show a good prognos...