Elongation factor, RNA polymerase II, 2 (ELL2) is expressed and regulated by androgens in the prostate. ELL2 and ELL-associated factor 2 (EAF2) form a stable complex, and their orthologs in Caenorhabditis elegans appear to be functionally similar. In C. elegans, the EAF2 ortholog eaf-1 was reported to interact with the retinoblastoma (RB) pathway to control development and fertility in worms. B...

Retinoblastoma (RB; encoded by RB1) is a tumor suppressor that is frequently disrupted in tumorigenesis and acts in multiple cell types to suppress cell cycle progression. The role of RB in tumor progression, however, is poorly defined. Here, we have identified a critical role for RB in protecting against tumor progression through regulation of targets distinct from cell cycle control. In analy...

Re-expression of a tumor suppressor in tumor cells that lack it is an effective way to study its functional activities. However, because tumor cells contain multiple mutations, tumor suppressor functions that are dependent on (an)other regulators are unlikely to be identified by its re-expression alone if the other regulators are also mutated. In this study, we show that re-expression of retino...

The Object of this paper is to design and analyze a Hysteresis modulation based sliding mode control (HMSMC) for positive output elementary super lift Luo converter (POESLLC), which is the start-of-the-art DC-DC converter. The positive output elementary super lift Luo converter performs the voltage conversion from positive source voltage to positive load voltage. This paper proposes a HMSMC cap...

People usually research modulation mode 3 of SVM for matrix converter discussed in this paper. Actually, other different modulation modes of SVM for matrix converter are worth studying. Two novel modulation modes are put forward for matrix converter for the first time in this paper, expanding its modulation modes of SVM. First, SVM for matrix converter is described. Then the 3 modulation modes ...

Submitted: Jun 8, 2013; Accepted: Jul 17, 2013; Published: Jul 25, 2013 Abstract: In this paper different types of converters based on different types of switching cells have been studied and designed. The analysis of each converter has been carried out. The main objective of analysis is to find out the advantages and disadvantages of each converter and to find the converter suitable for the gi...

In hybrid and renewable energy system, multiple-input converter is the best choice to integrate various input sources for supplying power to the load. In this paper, a multi-input DC-DC converter having ability to transfer energy from one of the sources to the energy storage source is presented. This feature results in improved reliability. In addition to this, energy sources having distinct vo...

Switched reluctance (SR) motors have high power density, high efficiency, high reliability, high fault tolerance, and low manufacturing cost. Thus, these motors have a high potential than other machines such as permanent magnet brushless motor, high-temperature super conductor motor, etc.; hence, it is well-suited for electric marine propulsion. This paper presents a new power converter and ana...

Autophagy is a protective mechanism that renders cells viable in stressful conditions. Emerging evidence suggests that this cellular process is also a tumor suppressor pathway. Previous studies showed that cyclin-dependent kinase inhibitors (CDKI) induce autophagy. Whether retinoblastoma protein (RB), a key tumor suppressor and downstream target of CDKIs, induces autophagy is not clear. Here, w...

A Double input DC to DC converter for low voltage energy sources applications is proposed in this paper. The proposed converter is buck-boost converter which can step up or step down the input voltage according to output voltage required at load end. The converter is able to boost up voltage of energy sources such as solar photovoltaic and wind energy system of relatively low voltage. The conve...