نتایج جستجو برای: rat corpus cavernosum
تعداد نتایج: 341323 فیلتر نتایج به سال:
PURPOSE Electroporation is known to enhance the efficiency of gene transfer through a transient increase in cell membrane permeability. The aim of this study was to determine the optimal conditions for in vivo electroporation-mediated gene delivery into mouse corpus cavernosum. MATERIALS AND METHODS Diabetes was induced in C57BL/6 mice by intraperitoneal injections of streptozotocin. After in...
An adverse effect of the administration of luteinizing hormone-releasing hormone (LH-RH) analogue is impotence. The effects of LH-RH analogue injection on the function of the rabbit corpus cavernosum were investigated. Eighteen male rabbits were divided into three groups, i.e., LH-RH analogue injection, castration, and sham-operated control groups. After measurement of serum testosterone, the L...
1. In the rat corpus cavernosum (CC), the distribution of immunoreactivity for neuronal and endothelial NO synthase (nNOS and eNOS), and the pattern of NOS-immunoreactive (-IR) nerves in relation to some other nerve populations, were investigated. Cholinergic nerves were specifically immunolabelled with antibodies to the vesicular acetylcholine transporter protein (VAChT). 2. In the smooth musc...
BACKGROUND Patients undergoing radical prostatectomy (RP) are at high risk for erectile dysfunction (ED) due to potential cavernous nerve (CN) damage during surgery. Penile hypoxia after RP is thought to significantly contribute to ED pathogenesis. AIM We previously showed that corpora cavernosum smooth muscle cells (CCSMCs) undergo phenotypic modulation under hypoxic conditions in vitro. Her...
By using a combination of genetic, pharmacological, and anatomical approaches, we show that the melanocortin 4 receptor (MC4R), implicated in the control of food intake and energy expenditure, also modulates erectile function and sexual behavior. Evidence supporting this notion is based on several findings: (i) a highly selective non-peptide MC4R agonist augments erectile activity initiated by ...
Objective: The aim of this study was to determine the changes and underlying mechanisms of erectile organ structure and function in hyperlipidemic rats. Materials and Methods: Sixteen male rats were fed a normal diet to serve as controls, and the other sixteen rats were induced to develop hyperlipidemia with a high fat diet. After 4 months, the penile tissues were harvested and assessed for smo...
Background: Phenotypic modulation within corpus cavernosum smooth muscle cells (CCSMCs) plays a critical role in the pathogenesis of erectile dysfunction (ED), yet little is known regarding the effects of plateletderived growth factor-BB (PDGF-BB) on CCSMCs phenotype. Objective: The aim of the present study was to evaluate the effect of PDGF-BB on phenotypic modulation of CCSMCs. Method: Cell v...
PURPOSE Carbon monoxide (CO) may mediate smooth muscle relaxation in the rat corpus cavernosum smooth muscle (CCSM). We hypothesized that CO plays a role in neurally derived, frequency-dependent relaxation of rat CCSM. MATERIALS AND METHODS To study the effect of CO on CCSM relaxation induced by electrical field stimulation (EFS), a CCSM bundle was mounted on a force transducer and perfused w...
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