ITP is a rare disease, characterized by increased platelet destruction/suboptimal production; patients with have an risk of bleeds and disease management complex. We aimed to evaluate the current treatment paradigm for chronic primary assess impact on healthcare resource utilization in six European countries (DE, ES, FR, IT, NL, UK). Interviews were conducted 23 physicians 12 payors (June/July ...

Because most colorectal carcinomas appear to arise from adenomas, studies of different stages of colorectal neoplasia may shed light on the genetic alterations involved in tumor progression. We looked for four genetic alterations (ras-gene mutations and allelic deletions of chromosomes 5, 17, and 18) in 172 colorectal-tumor specimens representing various stages of neoplastic development. The sp...

Despite the fact that there are wastewater treatment plants (WWTPs) currently operational across Iran and great advances have been made in this area, there are still problems in the design, construction, and operation of WWTPs with large nonlinear systems, varying flow rates, and pollution charges. The objective of this study was to investigate the effect of operating parameters including the r...

Abstract :  Reovirus (respiratory enteric orphan virus), a naturally occurring benign human pathogen, has an inherent ability to target transformed and cancerous cells and cause their lysis, while leaving non-transformed cells relatively unaffected.  The efficiency of this innate oncolytic activity of reovirus correlates with expression of the ras oncogene.  Cells expressing ac...

BackgroundInternational data on the epidemiology, ventilation practice, and outcomes in patients undergoing abdominal robotic-assisted surgery (RAS) are lacking. The aim of study was to assess incidence postoperative pulmonary complications (PPCs), describe ventilator management after RAS.MethodsThis an international, multicentre, prospective 34 centres nine countries. Patients ≥18 yr age RAS w...

1. Abstract 2. Introduction 2.1. Mutated proteins can induce malignant transformation 2.2. Mutant ras-p21 Protein Is a Major Cause of Cancer 2.3. ras-induced signal transduction pathways 2.4. Direct interactions between ras-p21 and target proteins depends largely on two of its domains 2.5. How amino acid substitutions in ras-p21 can induce it to become oncogenic 3. Methods 3.1. Computational me...

One of the main concerns of scholars working in the field of EAP over the last 2decades has been raising the awareness of EAP students and publishers of genreconventions in academic journals. In line with the above concern, many studies haveaimed at exploring the general characteristics of research articles (RAs) in the field.Among these features, it seems that the generic moves and textuality ...

We previously reported (T. Enomoto et al., Cancer Res., 50: 6139-6145, 1990; T. Enomoto et al., Cancer Res., 51: 5308-5314, 1991) a significant frequency of activating point mutations in codon 12 of the c-K-ras-2 protooncogene in endometrial adenocarcinoma and its premalignant precursor lesions (series 1 and 2). To reveal the role of the p53 tumor suppressor gene in the development of endometri...

R-Ras has a high degree of sequence homology to Ras and to other members of the Ras subfamily including Rap, TC21 and M-Ras. Activated versions of Ras and TC21 are highly transforming in a variety of cell lines and mutated forms of both proteins have been found in human tumours. R-Ras interacts with many of the same proteins as Ras and TC21, including c-Raf1, and can induce transformed foci, al...