نتایج جستجو برای: raphe nucleus

تعداد نتایج: 113232  

Journal: :The Journal of comparative neurology 2000
R Fay L Kubin

Serotonin (5-HT) exerts excitatory effects in many brainstem regions involved in autonomic, somatic, motor, and sensory functions, and in control of vigilance. To determine the potential role of 5-HT2A receptors in these effects, we immunohistochemically mapped the distribution of 5-HT2A receptor-like protein in the rat pontomedullary brainstem. Areas containing the densest labeling included th...

Abbas Haghparast, Maryam Ziaei, Mehdi Ordikhani-Seyedlar, Mohammad Ebrahimzadeh-Sarvestani, Pegah Azizi,

A B S T R A C TIntroduction: The nucleus cuneiformis (NCF) and ventrolateral periaqueductal gray (vlPAG), two adjacent areas, mediate the central pain modulation and project to the nucleus raphe magnus (NRM). Methods: This study examined whether the antinociceptive effect of morphine microinjected into the NCF is influenced by inactivation of vlPAG and NRM in rats. Animals were bilaterally micr...

ژورنال: Anatomical Sciences Journal 2004
Behzadi, Zhila, Joghataei, Mohammad Taghi, Nikbakht, Farnaz,

Purpose: The nucleus raphe magnus (NRM) is a medullary nucleus containing serotonergic and non serotonergic neurons, both of which densely project to spinal cord. The goal of this study was to determine the role of these non serotonergic neurons in pain perception and their cytological changes after the specific lesion of bulbo-spinal serotonergic pathway. Materials and Methods: Male rats were...

2014
Mariano Soiza-Reilly Kathryn G. Commons

The dorsal raphe nucleus (DRN), representing the main source of brain's serotonin, is implicated in the pathophysiology and therapeutics of several mental disorders that can be debilitating and life-long including depression, anxiety and autism. The activity of DRN neurons is precisely regulated, both phasically and tonically, by excitatory glutamate and inhibitory GABAergic axons arising from ...

2011
Annamária Fejes Árpád Párdutz József Toldi László Vécsei

Migraine is one of the commonest neurological disorders. Despite intensive research, its exact pathomechanism is still not fully understood and effective therapy is not always available. One of the key molecules involved in migraine is glutamate, whose receptors are found on the first-, second- and third-order trigeminal neurones and are also present in the migraine generators, including the do...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1992
S B Kombian W F Colmers

Neuropeptide Y (NPY) has been shown to modulate synaptic transmission in both peripheral and central tissues via both pre- and postsynaptic mechanisms. In this study, we examined the effect of NPY and its analog, peptide YY (PYY), on slow synaptic potentials in the dorsal raphe nucleus in vitro using intracellular recording and single-microelectrode voltage-clamp techniques. NPY and PYY inhibit...

Journal: :Journal of applied physiology 2007
Mirela B Dias Tatiane B Nucci Lisandra O Margatho José Antunes-Rodrigues Luciane H Gargaglioni Luiz G S Branco

There is evidence that serotonin [5-hydroxytryptamine (5-HT)] is involved in the physiological responses to hypercapnia. Serotonergic neurons represent the major cell type (comprising 15-20% of the neurons) in raphe magnus nucleus (RMg), which is a medullary raphe nucleus. In the present study, we tested the hypothesis 1) that RMg plays a role in the ventilatory and thermal responses to hyperca...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1991
C Bendotti A Servadio R Samanin

Using in situ hybridization, we examined the distribution of the mRNA encoding for the growth-associated protein GAP-43 in the brain stem of adult rats. GAP-43 was expressed at the highest level in the nucleus raphe dorsalis (NDR), nucleus centralis superior (NCS), substantia nigra compacta (SNc), ventral tegmental area (VTA), and locus coeruleus (LC). An intermediate level of signal was detect...

Journal: :The Journal of comparative neurology 2010
Patrice G Guyenet Ruth L Stornetta Douglas A Bayliss

By definition central respiratory chemoreceptors (CRCs) are cells that are sensitive to changes in brain PCO(2) or pH and contribute to the stimulation of breathing elicited by hypercapnia or metabolic acidosis. CO(2) most likely works by lowering pH. The pertinent proton receptors have not been identified and may be ion channels. CRCs are probably neurons but may also include acid-sensitive gl...

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