Therapeutic Effect of Thyme (Thymus Vulgaris) Essential Oil on Patients with COVID19: A Randomized Clinical Trial

Objective: The aim of this study was to compare clinical outcomes of early versus delayed laparoscopic cholecystectomy (LC) in acute cholecystitis with more than 72 hours of symptoms. Background: LC is the treatment of acute cholecystitis, with consensus recommendation that patients should be operated within 72 hours of evolution. Data however remain weak with no prospective study focusing on p...

Background—Cardiac stress testing in patients at low risk for acute coronary syndrome is associated with increased false-positive test results, unnecessary downstream procedures, and increased cost. We judged it unlikely that patient preferences were driving the decision to obtain stress testing. Methods and Results—The Chest Pain Choice trial was a prospective randomized evaluation involving 2...

From the Rudd Center for Food Policy and Obesity (Roberto, Bragg, Schwartz, Musicus, Novak, Brownell), Yale University, New Haven, Connecticut; and the School of Public Health (Seamans), University of North Carolina, Chapel Hill, North Carolina Address correspondence to: Christina A. Roberto, PhD, The Rudd Center for Food Policy and Obesity, Yale University, PO Box 208369, New Haven CT 06511. E...

FABRY DISEASE IS A RARE X-LINKED recessive glycosphingolipid storage disorder that is caused by a deficiency of the lysosomal enzyme a-gal A (a-galactosidase A). Its incidence has been estimated to be 1:117 000 births. Globotriaosylceramide (Gb3), the glycosphingolipid substrate of this enzyme, accumulates within vulnerable cells, tissues, and organs of affected patients. Affected cell types in...

People with chronic musculoskeletal pain often experience pain-related fear of movement and avoidance behavior. The FearAvoidance model proposes a possible mechanism at least partly explaining the development and maintenance of chronic pain. People who interpret pain during movement as being potentially harmful to the organism may initiate a vicious behavioral cycle by generating pain-related f...

Background Thrombolytic therapy reduces mortality after acute myocardial infarction, even when treatment is initiated relatively late after onset of symptoms. The mechanism underlying this survival benefit is incompletely understood. Methods and Results In a prospectively designed ancillary study of a randomized, placebo-controlled trial of late thrombolytic therapy (LATE), the signal-averaged ...

Author Contributions: Dr Grey had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Role of the Sponsor: The Health Research Council of New Zealand had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manusc...