The objective of this study was to determine to what extent Latin American and Caribbean biomedical journals have endorsed and complied with clinical trial registration and reporting guidelines. A search of randomized clinical trials was carried out using the LILACS database. The randomized clinical trials identified through the search were assessed to determine whether trial registration and C...

A Notice of Retraction about the article “Experimental Assessment Carbon Dioxide Content in Inhaled Air With or Without Face Masks Healthy Children: Randomized Clinical Trial,” by Walach H, et al, has been published.

OBJECTIVE To examine the evidence for efficacy of surgery in the treatment of intractable epilepsy. METHOD Meta-analysis of randomized clinical trials. RESULTS One randomized clinical trial (n=80) and 3 observational studies are available. INTERPRETATION Compared to medical treatment, the surgery increases the proportion of patients who were free of seizure impairing awareness at 1 year (...

objective: to evaluate the potential advantages of imipenem/cilastatin in control of fever in neutro-penic hsct recipients.patients and method: in this single-center study, 111 consecutive febrile episodes in 104 neutropenic hsct recipients with a mean age of 26 years were randomized to treatment either with imipenem/cilastatin 1 g, iv, q8h or cefepime (our standard regimen) 2 g, iv, q8h. if fe...

background: despite major advances in assisted reproductive techniques, the implantation rates remain relatively low. some studies have demonstrated that intrauterine infusion of granulocyte colony stimulating factor (g-csf) improves implantation in infertile women. objective: to assess the g-csf effects on ivf outcomes in women with normal endometrial thickness. materials and methods : in this...

background: many workers suffer from low-back pain. type and severity of spinal complaints have relationship with work load. lack of adherence to ergonomics recommendations among the important causes of low-back pain. objective: to assess the effect of 3 ergonomics training programs on the prevalence of lowback pain among workers of an iranian automobile factory. methods: in a parallel-design 4...

Interim analysis of a multicenter, randomized, clinical trial (Swedish Drug Elution Trial in Peripheral Arterial Disease) between November 5, 2014, and December 10, 2018. About one-half almost 2300 patients were treated with paclitaxel-coated devices uncoated devices. Approximately 25% died each group during mean follow-up 2.5 years. During the entire period, there was no significant difference...

Large well-designed clinical efficacy and safety randomized clinical trials (RCTs) are required to achieve regulatory approval of new drug treatments. The objective of this article is to make recommendations for the criteria for defining and selecting the clinical trial study population, design and efficacy outcomes measures which comprise ideal premature ejaculation (PE) interventional trial m...

BACKGROUND While the randomized clinical trial is considered to provide the highest level of evidence in clinical medicine, its superiority to other study designs in the context of prevention studies is debated. The purpose of this review was (i) to gather evidence about challenges facing both randomized controlled trials and observational designs for the conduct of population-based chronic dis...