BACKGROUND The Nutrition Embedded Evaluation Programme Impact Evaluation (NEEP-IE) study is a cluster randomised controlled trial designed to evaluate the impact of a childcare centre-based integrated nutritional and agricultural intervention on the diets, nutrition and development of young children in Malawi. The intervention includes activities to improve nutritious food production and traini...

Abstract Introduction Challenges in surgical training have led to the exploration of technologies such as augmented reality (AR), which present novel approaches teaching orthopaedic procedures medical students. The aim this double-blinded randomised-controlled trial was compare validity and effect AR traditional on students understanding total knee arthroplasty (TKA). Methods Twenty from 7 UK u...

BACKGROUND A cluster randomised controlled trial (RCT) of a national Kenyan mental health primary care training programme demonstrated a significant impact for health workers on the health, disability and quality of life of their clients, despite a severe shortage of medicines in the clinics. In order to better understand the potential reasons for the improved outcomes in the intervention group...

The conclusion from the randomised badger culling trial was that localised badger culling not only fails to control but can actually increase the incidence of bovine tuberculosis in cattle. Professor Simon More and colleagues from University College Dublin question that conclusion, arguing that the data do not provide sufficient evidence to rule out alternative hypotheses.

INTRODUCTION Polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes (POEMS) syndrome is a fatal systemic disorder associated with plasma cell dyscrasia and the overproduction of the vascular endothelial growth factor (VEGF). Recently, the prognosis of POEMS was substantially improved by introduction of therapeutic intervention for myeloma. However, no randomised clinical trial...

BACKGROUND Physical activity levels are low amongst adolescent girls, and this population faces specific barriers to being active. Peer influences on health behaviours are important in adolescence, and peer-led interventions might hold promise to change behaviour. This paper describes the protocol for a feasibility cluster randomised controlled trial of Peer-Led physical Activity iNtervention f...

OBJECTIVE To assess the benefits and harms of targeting intensive versus conventional glycaemic control in patients with type 1 diabetes mellitus. DESIGN A systematic review with meta-analyses and trial sequential analyses of randomised clinical trials. DATA SOURCES The Cochrane Library, MEDLINE, EMBASE, Science Citation Index Expanded and LILACS to January 2013. STUDY SELECTION Randomise...

and coronary heart disease, Part 2 short-term reductions in blood pressure: overview of randomised drug trials in their epidemiological context. Lancet 1990; 335: 827–38. [8] Neaton JD, Grimm RH, Prineas RJ et al. Treatment of Mild Hypertension Study: final results. JAMA 1993; 270: 713–24. [9] Hansson L, Zanchetti A, Carruthers SG et al. Effects of intensive blood pressure lowering and low dose...