[(11)C]-choline is an effective PET tracer used for imaging of neoplastic lesions and metastases of the prostate cancer. However, its production can be a challenge for manufacturers, as it has not yet been described in Polish or European pharmacopoeia. In this study the technical aspects of [(11)C]-choline production are described and detailed process parameters are provided. The quality contro...

beta-emitting 166Ho (t1/2 = 26.78 hours, E(beta)max = 1.8 MeV) complexed with the phosphonic acid chelator, 1,4,7,10 tetraazacyclododecane-1,4,7,10-tetra(methylene phosphonic acid) (DOTMP) at a ligand-to-metal ratio of 1.5:1 binds to bone. This radioactive complex is a marrow-ablating radiopharmaceutical that appears useful for preparation of bone marrow (BM) transplant recipients without the m...

The classical isoperimetric problem seeks the least-area way to enclose a single region of prescribed volume. About 200 BC, Zenodorus argued that a circle is the least-perimeter enclosure of prescribed area in the plane (see [Heath 60]). In 1884, Schwarz [Schwarz 1884] proved by symmetrization that a sphere minimizes surface area for a given volume in R. Isoperimetric problems arise naturally i...

Introduction. Rhenium-188 has found wide application in nuclear medicine for the treatment of metastatic lesions skeletal system and joint diseases such as rheumatoid arthritis synovitis. Also, 188 Re-radiopharmaceuticals are being developed palliative hepatocellular carcinoma others. Immediately after first clinical trials Re-radiopharmaceuticals, when information on clinically effective admin...