Skeletal metastatic disease occurs in 20-35 per cent of patients with a malignancy (1,2). Lung, breast, genitourinary and gastro-intestinal tumours account for 80 per cent of primary sites. Breast is the commonest primary in females and prostate the commonest in males. Metastases are usually multiple but solitary deposits occur in approximately 10 per cent. The axial spine is a common site for ...

The Proton Therapy Center in Orsay (CPO) and CEA/DAPNIA launched the joint project on Monte Carlo modeling of a CPO beam line with the aim to achieve a prediction of dose distribution in all the calibration configurations (depth and the shape of the tumor) better than 2%. The calculation module is intended to be used for the absolute dosimetry of the clinical beam (patient Quality Assurance – Q...

UNLABELLED Prostate-specific membrane antigen (PSMA) is an excellent target for radionuclide therapy of metastasized castration-resistant prostate cancer (mCRPC). Besides high affinity and long tumor retention, the DOTA-conjugated ligand PSMA-617 has low kidney uptake, making it an excellent choice for therapeutic application. We retrospectively report our experience with (177)Lu-PSMA-617-targe...

Adjuvant therapy of differentiated thyroid cancer with radioactive iodine ((131)I) is a standard procedure for the ablation of remnant thyroid tissue following surgery and for the treatment of iodine-avid metastases. Presently, there are two dosimetric concepts for the treatment of thyroid cancer using radioiodine: a) the bone marrow dose limited approach and b) lesion-based dosimetry. Both con...

The total dose absorbed on the tumor cell from skin patch sources used in clinical superficial brachytherapy should be limited within target volume order to minimize potential side effects. Average range of beta particles tissue may exceed thickness a beyond volume, causing effects by damaging deeper located healthy and bone underneath tumor. It is desired possible selecting short-range radionu...

PURPOSE Computational simulation is a simple and practical way to study and to compare a variety of radioisotopes for different medical applications, including the palliative treatment of bone metastases. This study aimed to evaluate and compare cellular effects modelled for different radioisotopes currently in use or under research for treatment of bone metastases using computational methods. ...

Introduction: Thyroid cancer is at the ninth from ten of common malignant cancer. A man has higher risk to get Thyroid cancer that a woman has. This organ is lain near human neck. The use of radioactive I-131, I-123 and Tc-99m for diagnosis of thyroid cancer has a risk where other organs around Thyroid will accept dose of radiation. One of the risks is large dose which is accep...

Background: In this study, human absorbed dose of a newly introduced bone imaging agent, 68Ga-(4-{[(bis(phosphonomethyl))carbamoyl]methyl}-7,10-bis(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl) acetic acid (68Ga-BPAMD), was estimated based on the rats data. Materials and Methods: 68Ga was obtained from the 68Ge/68Ga generator and it's radionuclidic and radiochemical purities were investigate...

background: recent studies in eye plaque brachytherapy have shown a considerable difference between the dosimetric results using water phantom and a model of human eye containing realistic materials. in spite of this fact, there is a lack of simulation studies based on such a model in proton therapy literatures. in the presented work, the effect of utilizing an eye model with ocular media on pr...

This study explores how the metal materials of the applicator influence the dose distribution when performing brachytherapy for cervical cancer. A pinpoint ionization chamber, Monte Carlo code MCNPX, and treatment planning system are used to evaluate the dose distribution for a single Ir-192 source positioned in the tandem and ovoid. For dose distribution in water with the presence of the tande...