In collaboration with GSI Biophysics, the microbeam, operated with ions from the UNILAC linear accelerator of GSI, is routinely employed for targeted irradiation of living cells in culture [1]. A custom-made fluorescence microscope is used both for beam targeting and for cell observation via fluorescent dyes that specifically highlight the biological agent of interest. Green Fluorescent Protein...

PURPOSE Targeted radiotherapy using Auger electrons presents multiple advantages and challenges. The advantageous characteristics of this type of radiotherapy can explain the growing interest in these specific electrons for cancer therapy. During the last decade, Technetium-99m ((99m)Tc) has been used as an imaging agent and only recently has it been analysed as a potential therapeutic agent. T...

The concept of dose-response linearity has been in practice for risk assessment of chemical carcinogens and ionising radiation for the past 30 years. But in recent years the evidence from cancer mortality studies and new radiobiological phenomena such as genomic instability, the bystander effect and adaptive response have challenged this accepted hypothesis questioning whether low dose linearit...

Likewise, ongoing light ions therapy projects in Europe are based on a strong radiobiological rationale, supported by the preliminary clinical results from NIRS and GSI that tend to confirm the hypothesis of the expected therapeutic gain using High LET particles for radio-resistant tumors [2-4]. However, long-term results in prospective studies are still mandatory to assess the magnitude of the...

BACKGROUND The unique radiobiological properties of protons have been understood for many years. In addition, many of the clinical benefits of radiotherapy were first noted in tumors involving the skull base. More public attention has been given to proton beam therapy due to the increasing number of centers now in operation or in the planning stages for offering this treatment option. METHODS...

The published data regarding radiation therapy of tumors treatment with ultrahigh dose rate has been analyzed. In 2014, the authors, among whom most mentioned are Vincent Favaudon and MarieCatherine Vozenin, named it flash effect. Note, however, that a member our laboratory, S.V. Kozin in collaboration ITEP researchers, back 1984, having studied reaction graft mice skin after proton irradiation...