the musculoskeletal extrapulmonary tuberculosis is uncommon, the upper extremity tuberculosis is not common and the mycobacterial involvement of skin of hands and synovial sheath of tendons is rare. this prospective observational study was undertaken between august  2014 and december 2015 in a tertiary referral hospital. patients attending with suspected primary tuberculosis of soft tissue of t...

Introduction. Basal cell carcinoma is the most common tumour of eyelids and periocular region throughout world. BCC represents 90 % malignant tumours eyelids, predominantly in male population. The incidence higher age over 60. Over 50% initially occur on lower lid inner angle. Research objectives. Literature review epidemiology, aetiopathogenesis, clinical attributes, diagnostics, treatment his...

MutY adenine glycosylases prevent DNA mutations by excising adenine from promutagenic 8-oxo-7,8-dihydroguanine (OG):A mismatches. Here, we describe structural features of the MutY active site bound to an azaribose transition state analog which indicate a catalytic role for Tyr126 and approach of the water nucleophile on the same side as the departing adenine base. The idea that Tyr126 participa...

BACKGROUND Intracranial fungal masses are uncommon diseases, but their incidence is increasing, most often due to the prolonged survival of patients with different immunodeficiencies. The management of patients with intracranial fungal masses included stereotactic biopsy for diagnosis, partial or radical surgery excision and prolonged antifungal therapy. AIMS We report the case of a 51-year-o...

Background. Over the past ten years oncological outcomes achieved by local excision techniques (LETs) as the sole treatment for early stages of rectal cancer (ESRC) have been often disappointing. The reasons for these poor results lie mostly in the high risk of the disease's diffusion to local-regional lymph nodes even in ESRC. Aims. This study aims to find the correct indications for LET in ES...

Prior to the introduction of improved surgical techniques such as total mesorectal excision, local recurrence rates after resection were unacceptably high with surgery alone. Phase III trials were designed to determine the benefit of the addition of radiotherapy to radical surgery, and these have reported significant reductions in local recurrence. Two different strategies were evaluated in the...