radiation therapy is considered as one of the main methods in cancer treatment. in this method, determination of exact location and geometric properties of tumor is necessary for treatment planning that leads to increased accuracy and output of treatment and reduction of healthy tissue dose. for this purpose, the aim of the present study has been physiological transmission of gallium as a pharm...

Purpose: Carcinogenesis is an adaptive process between nascent tumor cells and their microenvironment, including the modification of inflammatory responses from antitumorigenic to protumorigenic. Radiation exposure can stimulate inflammatory responses that inhibit or promote carcinogenesis. The purpose of this study is to determine the impact of radiation exposure on lung cancer progression in ...

The vascular endothelial growth factor receptor (VEGFR) tyrosine kinases are being explored as targets for antiangiogenic cancer therapy. Radiotherapy also inhibits tumor growth and affects vasculature. We investigated the combination of the potent VEGFR tyrosine kinase inhibitor AZD2171 and ionizing radiation in cell culture and mouse models of lung cancer. We show that ionizing radiation indu...

Aggressive treatment, including resection of both metastasis and primary tumor, has been studied for non-small cell lung cancer patients with synchronous solitary brain metastasis. Involvement of mediastinal lymph nodes is considered a poor prognostic factor and a contraindication to surgical resection of the primary lung tumor after treatment for brain metastasis. Here we present the case of a...

Combination therapy for lung cancer has garnered widespread attention. Radiation therapy, gene therapy, and molecular targeted therapy for lung cancer have certain effects, but the disadvantages of these treatment methods are evident. Combining these methods can decrease their side effects and increase their curative effects. In this study, we constructed a pYr-ads-8-5HRE-cfosp-iNOS-IFNG plasmi...

The imaging revolution with Ultrasound, Computed Tomography, and Magnetic Resonance Imaging entered the world of treatment planning in external beam radiation therapy in the 80ies and 90ies, step by step (9). With the support of modern computer technology, this has led to sophisticated, widespread, 3D sectional image based treatment planning, that nowadays increasingly forms an essential integr...

tuberculosis (tb) is the most common infectious cause of human death. after the lung, genitourinary tract is the most common site for tb infection. pelvic tuberculosis should be considered in young women presented with pelvic mass, ascites, fever, an elevated ca125 level, negative cytology, and positive history of contact with affected person. a 24- year- old girl presented as stage iv ovarian ...

objective: amiodarone as an iodinated benzofuran derivative is a potent antiarrhythmic agent currently used for the treatment of ventricular arrhythmias. pulmonary toxicity is one of the complications of amiodarone therapy. the aim of this study was to determine the toxicity of amiodarone for pneumocytes. materials and methods: 14 male white new zealand rabbits were divided in a control group a...

The vascular endothelial growth factor receptor (VEGFR) tyrosine kinases are being explored as targets for antiangiogenic cancer therapy. Radiotherapy also inhibits tumor growth and affects vasculature. We investigated the combination of the potent VEGFR tyrosine kinase inhibitor AZD2171 and ionizing radiation in cell culture and mouse models of lung cancer. We show that ionizing radiation indu...

Lung cancer is the leading cause of cancer-related death in the United States. There was rapidprogress in the treatment of lung cancer duringpast decades, but local control and survival rates are still poor. Radiation therapy has been an indispensable part of the management of lung cancer, and a recent paradigm is concurrent chemoradiation therapy. Many novel chemotherapeutic agents were recent...