During the early postnatal age environmental signals underlie development of sensory systems. The visual system is considered as an appropriate system for evaluation of the role of sensory experience in postnatal development of sensory systems. In this study we evaluated the effect of visual deprivation on the usage of visuospatial cues in navigation of radial arm maze. Light (LR) and dark rear...

To investigate cognitive and general performance effects of low-level exposure to an organophosphorus chemical warfare agents (CWA), we evaluated behavior in rats inhalation-exposed (whole body, 60 min duration) to GB (1.7 mg/m3 – 4.0 mg/m3 X 1; 4.0 mg/m3 x 3) and GF (1.6-5.2 mg/m X 1). Before exposure, rats were trained on a variable-interval 56 sec schedule of reinforcement (VI56), which serv...

Metabotropic glutamate receptor 7 (mGluR7), a receptor with a distinct brain distribution and a putative role in anxiety, emotional responding, and spatial working memory, could be an interesting therapeutic target for fear and anxiety disorders. mGluR7-deficient (mGluR7-/-) mice showed essentially normal performance in tests for neuromotor and exploratory activity and passive avoidance learnin...

Object-place paired associate learning has been used to test hypotheses regarding the neurobiological basis of memory in rodents. Much of this work has focused on the role of limbic and hippocampal-parahippocampal regions, as well as the use of spatial information derived from allothetic visual stimuli to determine location in an environment. It has been suggested that idiothetic self-motion (v...

Consolidation processes, involving synaptic and systems level changes, are suggested to stabilize memories once they are formed. At the synaptic level, dendritic structural changes are associated with long-term memory storage. At the systems level, memory storage dynamics between the hippocampus and anterior cingulate cortex (ACC) may be influenced by the number of sequentially encoded memories...