It has been more than 20 years since Dr. Mattie Hendrick, a veterinary pathologist at the University of Pennsylvania, published her article titled “Postvaccinal sarcomas in the cat: Epidemiology and electron probe microanalytical identification of aluminum” in Cancer Research, first linking vaccination to sarcoma development (1). Dr. Hendrick initially brought her concerns to the forefront in 1...

During 2004, 49 states and Puerto Rico reported 6,836 cases of rabies in nonhuman animals and 8 cases in human beings to the CDC, representing a 4.6% decrease from the 7,170 cases in nonhuman animals and 3 cases in human beings reported in 2003. Approximately 92% of the cases were in wildlife, and 8% were in domes­ tic animals (compared with 91% and 9%, respectively, in 2003). Relative contribu...

During 2004, 49 states and Puerto Rico reported 6,836 cases of rabies in nonhuman animals and 8 cases in human beings to the CDC, representing a 4.6% decrease from the 7,170 cases in nonhuman animals and 3 cases in human beings reported in 2003. Approximately 92% of the cases were in wildlife, and 8% were in domestic animals (compared with 91% and 9%, respectively, in 2003). Relative contributi...

There is overwhelming evidence that the 4-dose vaccine schedule as part of postexposure prophylaxis to prevent human rabies for previously unvaccinated persons, as recommended by the Advisory Committee on Immunization Practices, United States in 2009, is safe and effective. When used appropriately with timely wound care and administration of human rabies immune globulin, the administration of 4...

This study determined the proportion of captive juvenile and adult African wild dogs (Lycaon pictus) that developed protective titres of rabies neutralising antibodies following ingestion of a chicken head bait/SAG-2 oral rabies vaccine combination. A single chicken head containing 1.8 ml of SAG-2 vaccine (10(8.0) TCID50/ml) in a plastic blister was fed to each of eight adult and three juvenile...

Animals imported from abroad are a cause of rabies outbreaks in many countries. Therefore, serology testing for dogs and cats traveling is an important measure to reduce the incidence rabies. Rabies virus antibodies were measured sera collected 2,367 894 between 2017 2021. A serum sample with value 0.5 IU/mL or higher was considered pass. The overall pass rates 96.4% 98.4% cats. mean neutraliza...

should be administered on days 3, 7 and 14. The full dose of immunoglobulin should be injected in the edges of the wound, and if this were not possible any remaining volume should be injected intramuscularly in a site distant from vaccine administration. None of the patients had side effects from the vaccine or the rabies immunoglobulin, which confirms their safety profiles. Since 1979, all cas...

BACKGROUND GMZ2 is a fusion protein of Plasmodium falciparum merozoite surface protein 3 (MSP3) and glutamate rich protein (GLURP) that mediates an immune response against the blood stage of the parasite. Two previous phase I clinical trials, one in naïve European adults and one in malaria-exposed Gabonese adults showed that GMZ2 was well tolerated and immunogenic. Here, we present data on safe...

Rabies is the oldest most feared zoonotic disease of world, affecting animals and human beings, responsible for approximately 55,000 deaths annually worldwide. virus (RABV) belongs to genus Lyssavirus, family Rhabdoviridae, under order Mononegavirales. The transmission RABV mainly occurred through bite rabid in 99% cases dogs are spread virus. present study was conducted molecular characterizat...

Modified vaccinia virus Ankara (MVA) has become a vaccine vector of choice for recombinant vaccine development. A MVA-based rabies vaccine would be advantageous for use as a vaccine for dogs (and wildlife), particularly if it proves innocuous and efficacious by the oral route. Here, the generation and immunological testing of a recombinant MVA expressing a rabies virus glycoprotein gene is desc...